Carprofen 53716-49-7

About Carprofen 53716-49-7

Carprofen is a non-steroidal anti-inflammatory drug (NSAID) primarily used in veterinary medicine, especially for dogs, to relieve pain and inflammation associated with osteoarthritis, post-operative recovery, and musculoskeletal disorders.

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Chemical Information:

• Chemical Name: 6-Chloro--methylcarbazole-2-acetic acid

• Molecular Formula: CHClNO

• Molecular Weight: 273.72 g/mol

• CAS Number: 53716-49-7

• EINECS Number: 258-995-4

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Appearance:

• Form: Crystalline powder

• Color: White to off-white

• Odor: Odorless

• Solubility:

  • Water: Slightly soluble

  • Alcohol, DMSO, and other organic solvents: Soluble

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Primary Uses:

• Dogs:

  • Treatment of pain and inflammation from osteoarthritis or surgery.

  • Available in chewable tablets, caplets, and injectable solutions.

• Other Animals:

  • Occasionally used off-label in cats, horses, or small mammals, under strict veterinary supervision.

• Human Use:

  • Previously investigated for human use but withdrawn due to liver side effects in some cases. Not approved for human use today.

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Mechanism of Action:

• Inhibits cyclooxygenase (COX) enzymes, mainly COX-2, reducing the production of prostaglandins, which are mediators of pain and inflammation.

• Carprofen is considered to have COX-2 selectivity, which may reduce the risk of gastrointestinal side effects compared to non-selective NSAIDs.

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Dosage Forms:

• Chewable tablets: 25 mg, 75 mg, 100 mg

• Caplets and injections (typically 50 mg/mL solution)

• Oral dosing for dogs: 2 mg/lb (4.4 mg/kg) daily, often divided into 2 doses

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Side Effects in Animals:

• Common: Vomiting, diarrhea, loss of appetite

• Serious: Liver enzyme elevation, kidney issues, gastrointestinal ulceration

• Regular blood tests are recommended during long-term use.

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Key Physical Properties

Carprofen presents as a white crystalline, odorless powder with a molecular weight of 273.714 grams. It remains stable for up to five years under proper room temperature storage. The compound has negligible loss on drying (0.5%), and while it decomposes before boiling, it melts between 214216C. Its solubility profile includes slight water solubility and ready dissolution in alcohol, DMSO, and similar solvents.


Safety and Regulatory Status

Despite prior investigations into its use for human medicine, Carprofen is no longer approved for human therapeutic applications due to the risk of liver-related side effects in some patients. It is crucial to note that contemporary regulatory guidelines do not permit its use in humans, and any handling should adhere to established safety protocols provided by the distributor or manufacturer.