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Pantoprazole Sodium Powder

Price 2300.0 INR/ Kilograms

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MOQ : 25 Kilograms

Pantoprazole Sodium Powder Specification

Storage
Room Temperature

Ph Level
pH between 9.0 and 10.5

Structural Formula
OCF2 | C6H3 - S(=O) - CH2 - Pyridine ring with two methoxy groups \ N Benzimidazole ring

Boiling point
586.9 C at 760 mmHg

Solubility
Freely soluble approximately 20 mg/mL or higher at room temperature

Heavy Metal (%)
Usually 20 parts per million (ppm) total heavy metals

Melting Point
225 C to 230 C

Shelf Life
3 Years

Molecular Formula
C H F N NaO S 1.5H O

Particle Size
5 to 100 micrometers ( m)

Molecular Weight
432.4 Kilograms (kg)

EINECS No
68693-66-9

Smell
No Smell

Taste
Bitter

HS Code
2933.39

Loss on Drying
For pantoprazole sodium sesquihydrate, the loss on drying is usually in the range of: 6.0% to 9.0%

Medicine Name
Protonix IV

Chemical Name
5-(Difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridinyl)methyl]sulfinyl]benzimidazole sodium salt

CAS No
138786-67-1

Type
Pharmaceutical Intermediates

Grade
Medicine Grade

Usage
Pantoprazole sodium, especially in its powder form for injection, is used to treat and manage various gastrointestinal conditions related to excess stomach acid. It belongs to the proton pump inhibitor (PPI) class of drugs.

Purity(%)
98.0% to 102.0%

Appearance
white to off-white crystalline powder.

Physical Form
Powder

Pantoprazole Sodium Powder Trade Information

Minimum Order Quantity
25 Kilograms

FOB Port
Mumbai Port

Payment Terms
Letter of Credit at Sight (Sight L/C), Letter of Credit (L/C), Cash Against Delivery (CAD), Cash Advance (CA), Cash in Advance (CID), Delivery Point (DP)

Supply Ability
100 Kilograms Per Day

Delivery Time
7 Days

Sample Available
No

Sample Policy
Free samples are available

Packaging Details
Drum Packing

Main Export Market(s)
Central America, North America, Asia, Australia, South America, Eastern Europe, Western Europe, Middle East, Africa

Certifications
WE PROVIDES ALL KIND OF CERTIFICATIONS AS YOU REQUIRED

About Pantoprazole Sodium Powder

We offer high-quality Pantoprazole Sodium in various packaging options at the best economic prices. The offered product belongs to the class of proton pump inhibitor that helps in decreasing the amount of acid produced in the stomach. This medicine is used for the treatment of erosive esophagitis and other conditions involving excess stomach acid. Pantoprazole Sodium provides relief to the patient from the condition by decreasing the amount of acid your stomach makes. This drug prevents from ulcers, heals acid damage to the stomach and esophagus, and may help prevent cancer of the esophagus. One must avoid this medicine if allergic to it.

Pantoprazole Sodium Powder Detailed Description

1. General Overview:
Pantoprazole sodium is a proton pump inhibitor (PPI) used to reduce the amount of acid produced in the stomach. The powder form is typically used for intravenous (IV) administration when oral administration is not possible or appropriate (e.g., in hospitalized patients with severe gastroesophageal reflux or gastrointestinal bleeding).

2. Composition and Formulation:

Active Ingredient: Pantoprazole sodium (usually in the form of pantoprazole sodium sesquihydrate)
Dosage: Commonly available in 40 mg per vial of pantoprazole sodium (equivalent to 40 mg of pantoprazole base)
Physical Form: A white to off-white lyophilized powder in a sterile vial
Reconstitution: Must be reconstituted with sterile 0.9% sodium chloride injection before administration

3. Mechanism of Action:

Pantoprazole is a proton pump inhibitor (PPI) that blocks the H+/K+ ATPase enzyme system at the secretory surface of the gastric parietal cell. This is the final step in acid production, leading to a significant and prolonged reduction in gastric acid secretion.

4. Indications:

Gastroesophageal reflux disease (GERD)
Zollinger-Ellison syndrome and other pathological hypersecretory conditions
Erosive esophagitis
Peptic ulcer disease, especially when IV administration is needed
Prevention of stress ulcers in critically ill patients

5. Preparation and Administration:

Reconstitution: The 40 mg vial is usually reconstituted with 10 mL of 0.9% Sodium Chloride Injection
Further Dilution (for IV infusion): The solution can be further diluted into 100 mL of 0.9% sodium chloride or 5% dextrose solution for a 15-minute infusion
IV Push: Can also be administered over 2 minutes without further dilution

6. Pharmacokinetics:

Bioavailability: 100% for IV; oral form is around 77%
Onset of Action: Within 15-30 minutes
Peak Plasma Concentration: 2.5 hours (IV)
Half-life: About 1 hour
Excretion: Primarily via urine and feces as metabolites

7. Side Effects:

Common: Headache, diarrhea, nausea, abdominal pain
Serious but rare: Hypomagnesemia, Clostridium difficile infection, bone fractures (with long-term use), allergic reactions
Injection-site reactions (e.g., thrombophlebitis)

8. Storage and Stability:

Store the dry powder at controlled room temperature (2025C)
Once reconstituted, the solution should be used immediately, though some formulations allow storage for up to 12 hours at room temperature or 24 hours refrigerated

9. Contraindications:

Known hypersensitivity to pantoprazole or other PPIs

10. Drug Interactions:

May interfere with drugs that require acidic pH for absorption, such as ketoconazole, ataza navir
May increase levels of warfarin, methotrexate, and other medications