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Benzocaine is a local anesthetic often used in topical applications for pain relief. Here is the technical data and description of Benzocaine powder:
Chemical Identity
Chemical Name: Ethyl 4-aminobenzoate
Synonyms: Ethyl p-aminobenzoate, Aethyl-p-aminobenzoate, Anaesthesin
CAS Number: 94-09-7
Molecular Formula: C9H11NO2
Molecular Weight: 165.19 g/mol
IUPAC Name: Ethyl 4-aminobenzoate
Chemical Name: Ethyl 4-aminobenzoate
Description:Benzocaine is a white, crystalline powder with a slightly bitter taste. It is commonly used as a topical analgesic in various formulations, including creams, ointments, and gels. It provides local relief from pain and discomfort caused by conditions like sunburn, insect bites, sore throats, and minor skin irritations.
Physical Appearance: White to off-white crystalline powder
Solubility: Slightly soluble in water; soluble in alcohol and chloroform
Melting Point: 8890C
Boiling Point: Decomposes before boiling (approximately 297C)
Density: 1.17 g/cm
Odor: Slight characteristic odor
Taste: Slightly bitter
Uses and Applications
Topical Anesthetic: It is used in topical formulations such as ointments, gels, and creams for relieving pain or itching from minor burns, insect stings, and other skin conditions.
Oral Care: Found in some throat lozenges and sprays for numbing the throat to relieve pain caused by minor sore throats.
Dental Anesthesia: In some over-the-counter oral gels for numbing the gums and oral cavity before dental procedures.
First Aid: Used in products like sunburn relief lotions or insect bite creams for localized pain relief.
Solubility:
Water: Slightly soluble in water (about 0.03% at 25C).
Organic Solvents: Soluble in alcohol, chloroform, and ether.
Ethanol: Soluble.
Other Solvents: Slightly soluble in propylene glycol.
Density: 1.17 g/cm
Refractive Index: ~1.555 at 20C.
pH: Benzocaine is a weak base. It does not have a specific pH value but can be dissolved in a suitable solvent like ethanol.
Uses and Applications:Benzocaine is widely used in both medical and cosmetic products due to its numbing properties.
Topical Anesthetic: Primarily used in topical applications such as gels, ointments, and creams to relieve pain and discomfort caused by conditions like insect bites, burns, sore throats, and minor cuts.
Oral Care: Found in some throat lozenges, sprays, or gels to relieve pain from sore throats or gum irritation.
Dental Anesthesia: Benzocaine is also used in over-the-counter dental gels to numb the gums before dental procedures like teething relief in children or for relieving pain from canker sores.
First Aid: In formulations for sunburn relief, insect bite creams, or in anti-itch creams due to its local anesthetic properties.
Cosmetic Products: Occasionally used in certain topical skin-care products to relieve irritation.
Contraindications: Benzocaine should not be used in individuals who are allergic to local anesthetics of the ester type (such as procaine or tetracaine). It should also be avoided in children under 2 years old for topical use, especially for throat pain, due to the risk of methemoglobinemia.
Safety Precautions:
Inhalation: Avoid inhaling powder form; can cause respiratory irritation.
Skin contact: Although it is used topically, long or repeated contact can cause skin irritation in sensitive individuals.
Eye contact: Avoid contact with eyes. In case of accidental contact, rinse eyes with plenty of water.
Stability: Benzocaine is stable under normal conditions of temperature and humidity. It does not degrade significantly when stored under recommended conditions.
Additional Information
Chemical Structure: Benzocaine consists of an aromatic amine group (para-amino group) attached to a benzene ring, with an ethyl ester group. The structure of benzocaine makes it an ester-type local anesthetic, which is why it shares some characteristics with other ester anesthetics like procaine.
Synthesis: Benzocaine is synthesized by esterifying para-aminobenzoic acid (PABA) with ethanol in the presence of a catalyst, typically sulfuric acid.
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