Cetrimide is a quaternary ammonium compound with strong antiseptic, disinfectant, and surfactant properties. It is widely used in pharmaceuticals, veterinary products, and cosmetic formulations as an antimicrobial agent.
| Property | Detail |
|---|---|
| Chemical Name | Trimethyl(tetradecyl)ammonium bromide or mixture of alkyltrimethylammonium bromides |
| Common Name | Cetrimide |
| CAS Number | 8044-71-1 |
| Molecular Formula | Variable, often approximated as CHBrN (depends on alkyl chain length) |
| Molecular Weight | 320400 g/mol (depending on exact composition) |
| Property | Value |
|---|---|
| Appearance | White or almost white, free-flowing powder |
| Odor | Faint characteristic odor |
| Solubility | Freely soluble in water and alcohol |
| pH (1% solution) | Typically 6.08.0 |
| Melting Point | Not sharply defined (depends on composition) |
| Loss on Drying | Usually < 2.0% (as per pharmacopeial standards) |
| Use | Function |
|---|---|
| Antiseptic creams and ointments | Prevents microbial growth in wounds and burns |
| Disinfectants | Used to clean surgical instruments, hospital surfaces |
| Shampoos (especially medicated) | Treats scalp conditions like dandruff, seborrheic dermatitis |
| Skin cleansers | For pre-surgical skin disinfection |
| Veterinary products | Topical disinfectants and wound care |
| Mouthwashes (limited use) | Antibacterial action in oral care |
Cetrimide is a cationic surfactant that disrupts the lipid membranes of bacteria and fungi, leading to cell lysis and death. It is effective against:
Gram-positive bacteria
Some Gram-negative bacteria
Certain fungi
Not effective against bacterial spores and some viruses unless combined with other agents (e.g., chlorhexidine).
Irritating to eyes and mucous membranes
Toxic if ingested in large quantities
Not recommended for use on deep wounds or in body cavities
Can cause skin sensitization or allergic reactions in sensitive individuals
| Property | Value |
|---|---|
| Pharmacopeial Grade | Listed in BP, USP, IP, and other pharmacopeias |
| HS Code | 3402.13 Non-ionic or cationic organic surface-active agents |
| Storage | Store in a cool, dry place in a tightly closed container, away from light and moisture |
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