Clorsulon Powder

Located in Gujarat, India, we specialize in manufacturing Clorsulon. Shreeji Pharma International manufactures all its products under GMP site, which has all the necessary regulatory support. The professionals pack this safely in different types of packaging, as per customer demand. The chemical formula of chlorsulon is C8H8Cl3N3O4S2, while the IUPAC name is 2-amino-6-(1,2,2-trichloroethenyl)benzene-1,3-disulfonamide. This benzenedisulfonamide derivative exhibits fasciolicidal properties. A narrow-spectrum flukicide, it is predominantly applied to livestock (cattle, sheep, and goats). A majority of its dosage forms are in the form of injections, but sometimes it is also available as a drench. Although the compound is easily absorbed into the bloodstream, maximum plasma levels are reached after 14 hours of ingestion.

• Name: 1,3-Benzenedisulfonamide,4-amino-6-(1,2,2-trichloroethenyl)-
• Superlist Name:   Clorsulon
• CAS No.: 60200-06-8
• Formula: C₈H₈Cl₃N₃O₄S₂
• Molecular Weight: 380.65
• Synonyms: 1,3-Benzenedisulfonamide,4-amino-6-(trichloroethenyl)- (9CI);4-Amino-6-(trichloroethenyl)-1,3-benzenedisulfonamide;Curatrem;L 631529;MK 401;
• EINECS:   262-100-2
• Density: 1.801 g/cm³
• Melting Point: 194-203C
• Boiling Point: 651.724 C at 760 mmHg
• Flash Point: 347.95 C
• Appearance: Crystalline solid

Clorsulon inhibits enzymes involved in the glycolytic pathway, which is the main source of energy for flukes. According to further research, Clorsulon inhibits 8-phosphoglycerate kinase and phospho-glyceromutase and blocks oxidation of glucose to acetate and propionate.

The benzene sulphonamide family of agents, including chlorsulon, are used to treat and control adult flukes. Cattle are treated with veterinary medicinal products containing clorsulon.

An invention discloses a method for preparing clorsulon by condensation with chloroform, chlorination with m-nitrobenzaldehyde at low temperature, hydrazine hydrate reduction, chlorosulfuric acid reduction, and finally ammonification. The present invention avoids the use of large benzene of toxic content; it also avoids the use of harmful chlorine, the reduction reaction employs hydrazine hydrate comparing environmental protection, and hydrazine hydrate reductions are smaller than those of iron powder; extremely good catalyzer iron trichloride, and absorbent charcoal carrier; nitrogen is able to provide good product protection, and yield meets bibliographical requirements; work simplification; reaction conditions are gentle, and environmental friendliness, has good prospects for commercial use.

In veterinary medicine, chlorsulon is an active ingredient that is narrow-spectrum antiparasitic. Livestock is treated with it to prevent liver flukes. It does not work on agricultural pests or household pests. It belongs to the sulphonamide chemical class.

Closulon is an anthelmintic with a narrow spectrum of activity against some flukes, like Fasciola hepatica. There is no effect on roundworms, tapeworms, or external parasites. In ruminants, it is used mostly as an injectable, very rarely as a drench, and usually in combination with ivermectin to increase its flukicidal effect.

Here are some possible side-effects of Ivermectin / Clorsulon-containing medicines. However, they are not always experienced. Occasionally, serious side effects can occur. If any of the following side-effects persist, speak to your doctor:

• Cough
• Itching of skin
• Dry skin
• Sore throat
• Fatigue

You should discuss Ivermectin / Clorsulon use with your doctor if you are taking any medications, over-the-counter products (e.g. vitamins, herbal supplements, etc. ), have any allergies or health conditions (e.g. pregnancy, upcoming surgery, etc.). Certain health conditions may make you particularly susceptible to side effects of medications. Consult your doctor or see the product insert for instructions. Your medical condition will determine your dosage. Let your doctor know if your condition persists or worsens. Below is a list of important counseling points:

• Asthma, bleeding disorders, or brain problems
• Breastfeeding or pregnant
• Taken on an empty stomach with water