08037400111
08037400111
Croscarmellose Sodium
230 INR/Kilograms
Product Details:
- Particle Size 25 to 55 m
- Structural Formula C28H30Na8O27
- Ph Level 5.7
- Melting Point 1710 C
- Taste Odorless
- Shelf Life 2 Years
- Loss on Drying 2.41= Not more than 0.5z
- Supply Ability : 100 Kilograms Per Day
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Price And Quantity
- 25 Kilograms
- 230 INR/Kilograms
- 200.00 - 300.00 INR/Kilograms
Product Specifications
- Dry Place
- 74811-65-7
- Sodium croscarmellose is an internally cross-linked sodium carboxymethylcellulose for use as a superdisintegrant in pharmaceutical formulations. E468 is the E number of crosslinked sodium carboxymethyl cellulose, used in food as an emulsifier.
- NA
- 98%
- Practically insoluble in acetone and anhydrous ethanol
- 2230
- No Smell
- 29420090
- Medicine Grade
- C8H16O8
- White Free Flowing Powder
- Powder
- 1272/2008
- 240.21 g/mol Kilograms (kg)
- Pharmaceutical Intermediates
- 2 Years
- 2.41= Not more than 0.5z
- 5.7
- Odorless
- 1710 C
- C28H30Na8O27
- 25 to 55 m
Trade Information
- Mumbai
- Letter of Credit at Sight (Sight L/C), Letter of Credit (L/C), Delivery Point (DP), Days after Acceptance (DA), Cash in Advance (CID), Cash Advance (CA)
- 100 Kilograms Per Day
- 7 Days
- Yes
- Free samples are available
- Drum Packing
- Asia, South America, Western Europe, Middle East, Central America, Eastern Europe, Australia, North America, Africa
- All India
- GMP/ ISO
Product Description
Croscarmellose sodium is a sodium salt of a cross-linked carboxymethylcellulose polymer. It is a commonly used pharmaceutical excipient that is used as a disintegrant in tablet formulations. It works by absorbing water and swelling rapidly, creating channels in the tablet that allow water to penetrate and dissolve the drug more easily. This helps to break down the tablet into smaller particles that can be easily dissolved in the gastrointestinal tract.
Croscarmellose sodium can improve the dissolution and bioavailability of drugs, enhance the stability of suspensions and emulsions, and control the rate of drug release in controlled-release tablets. It is also easy to use and cost-effective.
Croscarmellose sodium is generally considered safe for use in pharmaceuticals. It has been used for many years and is approved by regulatory agencies such as the FDA. While it is primarily used in pharmaceuticals, it can also be used in other industries such as food and cosmetics as a thickener, stabilizer, and emulsifier.
Croscarmellose Sodium Properties:
- CAS Number:74811-65-7
- Molecular Formula: C8H16O8
- Molecular Weight: 240.21
- Melting Point: 171 Degree Centigrade
- Boiling Point: 223 Degree Centigrade
- Solubility: Practically insoluble in anhydrous ethanol, toluene and acetone
- Synonyms: Carboxymethylcellulose Cellulose, carboxymethyl ether
Croscarmellose Sodium Applications:
1. Disintegrant: Croscarmellose sodium is primarily used as a disintegrant in tablet formulations. It helps to break down the tablet into smaller particles that can be easily dissolved in the gastrointestinal tract.
2. Binder: It is also used as a binder in the formulation of tablets. It helps to hold the ingredients together and prevent the tablet from falling apart.
3. Stabilizer: Croscarmellose sodium can also be used as a stabilizer in the formulation of suspensions and emulsions. It helps to prevent the separation of the different phases of the formulation.
4. Controlled release: Croscarmellose sodium can be used in the formulation of controlled-release tablets. It can control the rate of drug release by creating a barrier around the tablet and preventing the drug from being released too quickly.
5. Solubility enhancement: Croscarmellose sodium can enhance the solubility of poorly soluble drugs. It can do this by creating channels in the tablet that allow water to penetrate and dissolve the drug more easily.
How does it work:
CMC or carboxymethylcellulose (CMC) is a major ingredient in pharmaceuticals, and is widely used as a disintegrant in oral pharmaceutical formulations for capsules, tablets, and granules.
Side effects:
You cannot experience any "side effects" from croscarmellose sodium unless your body directly reacts to it. It has only been approved for use in small amounts by the Food and Drug Administration. It is not very likely to cause allergies. It can also cause adverse side effects in some, such as dyspepsia, hepatotoxicity, pancreatitis, interstitial nephritis, fever, headache, rash, nausea, vomiting, pneumonitis, pericarditis and so on.
Frequently Asked Questions:
1. What is croscarmellose sodium?
Ans: It is a sodium salt of a cross-linked carboxymethylcellulose polymer. It is a commonly used pharmaceutical excipient that is used as a disintegrant in tablet formulations.
2. How does croscarmellose sodium work?
Ans: It works by absorbing water and swelling rapidly, creating channels in the tablet that allow water to penetrate and dissolve the drug more easily. This helps to break down the tablet into smaller particles that can be easily dissolved in the gastrointestinal tract.
3. What are the benefits of using croscarmellose sodium in tablet formulations?
Ans: It can improve the dissolution and bioavailability of drugs, enhance the stability of suspensions and emulsions, and control the rate of drug release in controlled-release tablets. It is also easy to use and cost-effective.
4. Is croscarmellose sodium safe?
Ans: Yes, it is generally considered safe for use in pharmaceuticals. It has been used for many years and is approved by regulatory agencies such as the FDA.
5. Can croscarmellose sodium be used in other applications besides pharmaceuticals?
Ans: While croscarmellose sodium is primarily used in pharmaceuticals, it can also be used in other industries such as food and cosmetics as a thickener, stabilizer, and emulsifier. However, it is important to note that the grade of croscarmellose sodium used in pharmaceuticals may differ from the grade used in other industries, and care should be taken to ensure that the appropriate grade is used for the intended application.
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- Phone :08037400111
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