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Furosemide is a potent loop diuretic commonly used to treat conditions involving fluid retention, such as heart failure, chronic kidney disease, cirrhosis, and hypertension. Here are some key technical details about furosemide:
Chemical Information
IUPAC Name: 4-chloro-N-furfuryl-5-sulphamoyl-2-aminobenzoic acid
Molecular Formula: C12H11ClN2O5S
Molecular Weight: 330.75 g/mol
CAS Number: 54-31-9
Key Uses:
Edema: Furosemide is used to treat fluid retention caused by conditions such as heart failure, liver disease (cirrhosis), kidney disease, and other medical conditions that cause the body to hold on to extra fluid.
Hypertension: It can also be used to help lower blood pressure, often as part of a treatment plan for high blood pressure.
Dosage
The dosage of furosemide varies based on the condition being treated, the severity of the condition, and the patients response. The typical starting dose for adults is usually:
Edema: 2080 mg per day, which may be adjusted based on the patient's response.
Hypertension: Generally used as an adjunctive therapy, with doses typically starting at lower amounts.
Side Effects
Furosemide can cause several side effects, some of which can be serious:
Dehydration: As a potent diuretic, it can cause the body to lose too much fluid.
Electrolyte imbalances: Furosemide can lead to low potassium (hypokalemia), low sodium (hyponatremia), low calcium (hypocalcemia), and low magnesium (hypomagnesemia).
Low blood pressure (hypotension): Especially when starting the medication or increasing the dose.
Kidney damage: Prolonged use or high doses can affect kidney function, especially in patients with existing kidney disease.
Ototoxicity: High doses or rapid intravenous administration can lead to hearing damage, particularly in patients with pre-existing kidney problems.
Gout: Furosemide can increase the levels of uric acid in the blood, which might trigger gout attacks.
Rashes or allergic reactions: Some patients may develop skin reactions or more severe allergic responses.
Precautions
Electrolyte monitoring: Patients on furosemide should have regular blood tests to monitor their electrolyte levels, especially potassium and sodium.
Kidney function: Kidney function should be closely monitored, as furosemide can potentially cause kidney damage, especially at higher doses or with pre-existing kidney disease.
Pregnancy and breastfeeding: Furosemide is classified as a category C drug in pregnancy, meaning it should only be used if clearly needed. It passes into breast milk, so a doctor should be consulted if breastfeeding.
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