Papaverine Hcl POWDER

• CAS Number: 61-25-6
• Chemical Name: PAPAVERINE HYDROCHLORIDE; 61-25-6; Cardiospan; Cardoverina; Forpavin; Myobid
• Molecular Formula: C₂₀H₂₂ClNO₄
• Molecular Weight: 375.849 g/mol
• EINECS: 200-502-1
• Melting Point: 226 C (dec.)
• Boiling Point: 483.2 C at 760 mmHg
• Flash Point: 172.2 C
• Solubility: freely soluble in water
• Appearance: Crystalline solid

1. General Information:

• Name: Papaverine Hydrochloride

• Common Form: Fine crystalline powder

• Chemical Formula: C20H21NO4HCl

• Molecular Weight: 375.85 g/mol

• CAS Number: 61-25-6

• ATC Code: C04AD01

2. Physical and Chemical Properties:

• Appearance: White to off-white crystalline powder

• Solubility:

  • Freely soluble in water

  • Soluble in alcohol and chloroform

  • Practically insoluble in ether

• Odor: Odorless

• Taste: Slightly bitter

• pH (1% solution): Typically 4.0 5.5

• Melting Point: Around 147149C (decomposes)

3. Pharmacological Classification:

• Drug Class: Vasodilator, specifically a non-narcotic opium alkaloid

• Therapeutic Use:

  • Used primarily as a smooth muscle relaxant

  • Treats vasospasms, especially cerebral and peripheral vasospasms

  • Used in erectile dysfunction therapies (often in injectable form)

4. Mechanism of Action:

Papaverine works by inhibiting phosphodiesterase enzymes, particularly PDE10A, leading to an increase in cyclic AMP (cAMP) and cyclic GMP (cGMP) levels within smooth muscle cells. This results in smooth muscle relaxation, especially in vascular tissues, causing vasodilation and improved blood flow.

5. Applications:

• Medical:

  • Cerebral vasospasm (post subarachnoid hemorrhage)

  • Peripheral vascular diseases

  • Visceral spasm-related conditions (e.g., gastrointestinal or biliary colic)

• Research:

  • Used in pharmacological studies on PDE inhibition

  • Studied for its effect on cellular signaling pathways

• Compounding:

  • May be used to formulate injectable solutions or capsules in pharmaceutical compounding

6. Storage and Stability:

• Storage Conditions:

  • Store in a tightly closed container

  • Keep in a cool, dry, and well-ventilated area

  • Protect from light and moisture

• Shelf Life: Usually stable for 23 years under proper conditions

7. Handling and Safety:

• Precautions:

  • Avoid inhalation and contact with skin or eyes

  • Use appropriate personal protective equipment (PPE)

• Toxicity:

  • May cause hypotension, dizziness, gastrointestinal discomfort in case of overdose

• First Aid:

  • Inhalation: Move to fresh air, seek medical attention

  • Skin Contact: Wash with soap and water

  • Eye Contact: Rinse thoroughly with water and seek medical help

  • Ingestion: Seek immediate medical assistance

8. Regulatory Status:

• Prescription Drug: Regulated as a prescription-only medication in many countries

• Controlled Substance: Not classified as a controlled substance in most jurisdictions

• Regulatory Agencies: FDA (USA), EMA (Europe), CDSCO (India), etc.