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Papaverine Hcl POWDER Papaverine Hcl POWDER Papaverine Hcl POWDER Papaverine Hcl POWDER Papaverine Hcl POWDER Papaverine Hcl POWDER
Papaverine Hcl POWDER
Papaverine Hcl POWDER Papaverine Hcl POWDER Papaverine Hcl POWDER Papaverine Hcl POWDER Papaverine Hcl POWDER

Papaverine Hcl POWDER

1450.0 INR/Gram

Product Details:

  • Loss on Drying not more than 0.5% to 1.0% (w/w)
  • Shelf Life 3 Years
  • Molecular Weight 375.85 Kilograms (kg)
  • Molecular Formula C H NO HCl
  • Particle Size 10 to 100 microns ( m)
  • Heavy Metal (%) Typically, not more than 20 parts per million (ppm) (0.002%) according to pharmacopeial standards (USP, EP, BP).
  • HS Code 29419090
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Papaverine Hcl POWDER Price And Quantity

  • 1 Gram
  • 1450.0 INR/Gram
  • 25.00 - 50.00 INR/Gram

Papaverine Hcl POWDER Product Specifications

  • 1-[(3,4-Dimethoxyphenyl)methyl]-6,7-dimethoxyisoquinoline hydrochloride
  • Freely soluble approximately 2 mg/mL or higher at room temperature due to its hydrochloride salt form.
  • 98.0% to 101.0% (on dried basis)
  • Papaverine belongs to the group of medicines called vasodilators. Vasodilators cause blood vessels to expand, thereby increasing blood flow. This medicine is used to treat problems resulting from poor blood circulation.
  • 135 C
  • 4.0 to 5.5
  • Room Temperature
  • 200-502-8
  • 147 149 C (with decomposition)
  • 61-25-6
  • Bitter
  • No Smell
  • 10 to 100 microns ( m)
  • C H NO HCl
  • Powder
  • White to off-white
  • 375.85 Kilograms (kg)
  • not more than 0.5% to 1.0% (w/w)
  • 3 Years
  • OCH3 OCH3 | | ---C6-----C7--- | | N+ CH2 C6H3(OCH3)2 Cl | | C1 C5
  • Pavabid, Papacon, and Pavagen.
  • Medicine Grade
  • Typically, not more than 20 parts per million (ppm) (0.002%) according to pharmacopeial standards (USP, EP, BP).
  • Blood System Agents
  • 29419090

Papaverine Hcl POWDER Trade Information

  • Mumbai Port
  • Cash Against Delivery (CAD) Cash Advance (CA) Cash in Advance (CID) Delivery Point (DP) Letter of Credit at Sight (Sight L/C) Letter of Credit (L/C)
  • 100 Gram Per Day
  • 7 Days
  • Yes
  • Free samples are available
  • Drum Packing
  • North America South America Eastern Europe Western Europe Middle East Africa Australia Central America Asia
  • WE PROVIDES ALL KIND OF CERTIFICATIONS AS YOU REQUIRED

Product Description

Papaverine Hydrochloride Properties:

  • CAS Number: 61-25-6
  • Chemical Name: PAPAVERINE HYDROCHLORIDE; 61-25-6; Cardiospan; Cardoverina; Forpavin; Myobid
  • Molecular Formula: C20H22ClNO4
  • Molecular Weight: 375.849 g/mol
  • EINECS: 200-502-1
  • Melting Point: 226 C (dec.)
  • Boiling Point: 483.2 C at 760 mmHg
  • Flash Point: 172.2 C
  • Solubility: freely soluble in water
  • Appearance: Crystalline solid

Papaverine Hydrochloride, USP/EP is white to almost white in color, and comes as either a crystalline powder or as crystals. It is odorless. In terms of solubility, Papaverine Hydrochloride is sparingly soluble to soluble in water, is soluble in chloroform and is slightly soluble in alcohol.

1. General Information:

  • Name: Papaverine Hydrochloride

  • Common Form: Fine crystalline powder

  • Chemical Formula: C20H21NO4HCl

  • Molecular Weight: 375.85 g/mol

  • CAS Number: 61-25-6

  • ATC Code: C04AD01


2. Physical and Chemical Properties:

  • Appearance: White to off-white crystalline powder

  • Solubility:

    • Freely soluble in water

    • Soluble in alcohol and chloroform

    • Practically insoluble in ether

  • Odor: Odorless

  • Taste: Slightly bitter

  • pH (1% solution): Typically 4.0 5.5

  • Melting Point: Around 147149C (decomposes)


3. Pharmacological Classification:

  • Drug Class: Vasodilator, specifically a non-narcotic opium alkaloid

  • Therapeutic Use:

    • Used primarily as a smooth muscle relaxant

    • Treats vasospasms, especially cerebral and peripheral vasospasms

    • Used in erectile dysfunction therapies (often in injectable form)


4. Mechanism of Action:

Papaverine works by inhibiting phosphodiesterase enzymes, particularly PDE10A, leading to an increase in cyclic AMP (cAMP) and cyclic GMP (cGMP) levels within smooth muscle cells. This results in smooth muscle relaxation, especially in vascular tissues, causing vasodilation and improved blood flow.


5. Applications:

  • Medical:

    • Cerebral vasospasm (post subarachnoid hemorrhage)

    • Peripheral vascular diseases

    • Visceral spasm-related conditions (e.g., gastrointestinal or biliary colic)

  • Research:

    • Used in pharmacological studies on PDE inhibition

    • Studied for its effect on cellular signaling pathways

  • Compounding:

    • May be used to formulate injectable solutions or capsules in pharmaceutical compounding


6. Storage and Stability:

  • Storage Conditions:

    • Store in a tightly closed container

    • Keep in a cool, dry, and well-ventilated area

    • Protect from light and moisture

  • Shelf Life: Usually stable for 23 years under proper conditions


7. Handling and Safety:

  • Precautions:

    • Avoid inhalation and contact with skin or eyes

    • Use appropriate personal protective equipment (PPE)

  • Toxicity:

    • May cause hypotension, dizziness, gastrointestinal discomfort in case of overdose

  • First Aid:

    • Inhalation: Move to fresh air, seek medical attention

    • Skin Contact: Wash with soap and water

    • Eye Contact: Rinse thoroughly with water and seek medical help

    • Ingestion: Seek immediate medical assistance


8. Regulatory Status:

  • Prescription Drug: Regulated as a prescription-only medication in many countries

  • Controlled Substance: Not classified as a controlled substance in most jurisdictions

  • Regulatory Agencies: FDA (USA), EMA (Europe), CDSCO (India), etc.

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