Progesterone Chemical

Product Description

We are offering high quality of Progesterone. We are known for manufacturing,exporting, distributing, trading and supplying Progesterone in Gujarat, India. Further, this is safely packaged by our professionals in diverse packaging options that maintain its purity and effectiveness.

Shreeji Pharma International is leading Manufacturer, Exporter, Distributor, and Supplier of Progesterone in Gujarat. India. Shreeji Pharma International manufacturing & supplying all products under GMP site with all types of regulatory supports.

Shreeji Pharma International is the largest manufacturer, Exporter and supplier of Progesterone Nowadays Shreeji Pharma International is one of the leading manufacturer and exporter, who is manufacturing Progesterone as well as Intermediates of Progesterone.

Shreeji Pharma International is exporter, supplier, distributor and manufacturers of the Active Pharmaceuticals Ingredients in many countries for many years.

Shreeji Pharma International currently export Progesterone to countries like Gulf Countries, South East Asia countries, African Countries, CIS Countries, LATAMcountries, Central American Countries and in European countries

• Chemical Name: Pregn-4-ene-3,20-dione
• Common Name: Progesterone
• CAS Number: 57-83-0
• Molecular Formula: CHO
• Molecular Weight: 314.47 g/mol
• Appearance: White to off-white crystalline powder
• Odor: Odorless or faint odor
• Solubility: Practically insoluble in water; soluble in alcohol, acetone, dioxane, and vegetable oils
• Melting Point: 126131C
• Storage Conditions: Store in a cool, dry place at controlled room temperature (2025C), protected from light and moisture

Pharmacological Classification:

• Class: Natural progestin; female sex hormone
• Therapeutic Category: Hormone replacement, fertility treatments, gynecological therapies
• Mechanism of Action:Progesterone is a steroid hormone that binds to progesterone receptors in the female reproductive system. It regulates:Ovulation,Menstrual cycle,Maintenance of pregnancy It also transforms the endometrium for embryo implantation and reduces uterine contractions.

Applications:

• Used as an Active Pharmaceutical Ingredient (API) in:
• Hormone Replacement Therapy (HRT)
• Luteal phase support in assisted reproductive technology (ART)
• Treatment of amenorrhea, dysmenorrhea, and abnormal uterine bleeding
• Prevention of endometrial hyperplasia in estrogen therapy
• Available in oral capsules, vaginal suppositories, creams, injections (oily solutions)

Sources:

• Can be synthetic or bioidentical (from plant sterols like diosgenin from yam/soy)
• Micronized forms used to improve oral bioavailability
• Side Effects:Drowsiness, dizziness,Breast tenderness,Headache, mood swings,Bloating, nausea
• Irregular menstrual bleeding
• Rare: Allergic reactions, thromboembolic events

Precautions & Warnings:

• Use with caution in patients 
• Liver dysfunction
• History of thromboembolism
• Breast or genital cancers
• Monitor blood pressure and blood glucose in long-term users
• Not for use in pregnancy unless prescribed (some forms are pregnancy category B/D depending on route)
• Avoid alcohol and other sedatives during therapy

Warnings:

• Breast Cancer Risk: Long-term use, especially with estrogen (in hormone replacement therapy), may increase the risk of breast cancer.
• Thromboembolic Disorders: May increase the risk of blood clots (deep vein thrombosis, pulmonary embolism, stroke, myocardial infarction).
• Liver Dysfunction: Use with caution in patients with liver disease or impaired liver function. Can cause cholestatic jaundice or hepatic dysfunction.
• Visual Disturbances: Discontinue use if sudden vision changes, proptosis, diplopia, or migraine occur.
• Depression: May worsen pre-existing depression. Monitor closely in patients with a history of mood disorders.
• Allergic Reactions: Hypersensitivity to progesterone or formulation ingredients may cause rash, itching, or anaphylaxis in rare cases.

Precautions:

• Medical History Assessment: Evaluate personal/family history of cancer, thrombosis, stroke, and mental health conditions before prescribing.
• Pregnancy: Safe in early pregnancy for certain conditions (e.g., luteal phase support), but should be prescribed with clear indication and dose.
• Breastfeeding: Excreted in small amounts in breast milk. Generally considered safe, but caution is advised.
• Kidney Impairment: Use cautiously; dose adjustment may be needed.