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Acyclovir Acyclovir Acyclovir
Acyclovir
Acyclovir Acyclovir

Acyclovir

4100.0 INR/Kilograms

Product Details:

  • Boiling point Not applicable (decomposes before boiling)
  • Storage Room Temperature
  • Solubility Acyclovir is known for its poor water solubility, which affects its oral bioavailability and formulation development.
  • Melting Point 256.5 C (493.7 F)
  • HS Code 29335990
  • Loss on Drying Not more than 6.0% (when dried at 105 C)
  • Molecular Formula C8H10N5NaO3
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Acyclovir Price And Quantity

  • 4100.0 INR/Kilograms
  • 25 Kilograms
  • 25.00 - 50.00 INR/Kilograms

Acyclovir Product Specifications

  • C8H10N5NaO3
  • Medicine Grade
  • NMT 20 ppm (parts per million)
  • Acyclovir is used to treat the symptoms of chickenpox, shingles, herpes virus infections of the genitals (sex organs), the skin, the brain, and mucous membranes (lips and mouth), and widespread herpes virus infections in newborns. Acyclovir is also used to prevent recurrent genital herpes infections.
  • C8H11N5O3
  • 98%
  • Not applicable (decomposes before boiling)
  • Room Temperature
  • Not more than 6.0% (when dried at 105 C)
  • Pharmaceutical Intermediates
  • 59277-89-3
  • 256.5 C (493.7 F)
  • White crystalline powder
  • Acyclovir
  • 3 Years
  • 29335990
  • Micronized Acyclovir: D90 (90% of particles): 10 50 m D50 (median particle size): ~5 20 m D10: ~1 5 m
  • Acyclovir is known for its poor water solubility, which affects its oral bioavailability and formulation development.
  • Liquid
  • 2-amino-1,9-dihydro-9-[(2-hydroxyethoxy)methyl]-6H-purin-6-one
  • 225.21 Grams (g)

Acyclovir Trade Information

  • Mumbai
  • Cash Advance (CA), Cash in Advance (CID)
  • 1000 Kilograms Per Day
  • 7 Days
  • Yes
  • Free samples are available
  • DRUM
  • Western Europe, Middle East, Africa, Asia, Australia, Central America, North America, South America, Eastern Europe
  • WE PROVIDES ALL KIND OF CERTIFICATIONS AS YOU REQUIRED

Product Description

We are offering high quality Acyclovir.We are known for manufacturing, exporting, distributing, trading and supplying Acyclovir in Gujarat, India. Further, this is safely packaged by our professionals in diverse packaging options that maintain its purity and effectiveness.


Shreeji Pharma International is leading Manufacturer, Exporter, Distributor, and Supplier of Bisacodyl Acyclovir in Gujarat. India. Shreeji Pharma International manufacturing & gmp; supplying all products under GMP site with all types of regulatory supports.


Shreeji Pharma International is the largest manufacturer, Exporter and supplier ofAcyclovir nowadays Shreeji Pharma International is one of the leading manufacturer and exporter, who is manufacturing Acyclovir as well as Intermediates of Acyclovir.


Shreeji Pharma International is exporter, supplier, distributor and manufacturers of the Active Pharmaceuticals Ingredients in many countries for many years.


Shreeji Pharma International currently export Bisacodyl to countries likeGulf Countries, South East Asia countries, African Countries, CIS Countries, LATAM countries, Central American Countries and in European countries.


Acyclovir Technical Description

1. General Information

Generic Name: Acyclovir

Brand Names: Zovirax, Sitavig, Acyclovir Sodium (for injection)

Drug Class: Antiviral (Antiherpetic)

ATC Code: J05AB01

Molecular Formula: CHNO

Molecular Weight: 225.21 g/mol

CAS Number: 59277-89-3

Chemical Structure:
Acyclovir is a synthetic purine nucleoside analog structurally related to guanine.

2. Chemical Structure & Properties

IUPAC Name:
2-amino-1,9-dihydro-9-[(2-hydroxyethoxy)methyl]-6H-purin-6-one

LogP (Partition Coefficient): -1.56

Solubility:

Water: Slightly soluble (~1.2 mg/mL at 25C)

pKa: ~2.27 (acidic), ~9.25 (basic)

Appearance: White crystalline powder

3. Mechanism of Action

Acyclovir is selectively phosphorylated by viral thymidine kinase to acyclovir monophosphate, which is then converted by host enzymes to the active acyclovir triphosphate. This compound inhibits viral DNA polymerase and incorporates into viral DNA, leading to chain termination during DNA replication.

4. Indications

Herpes Simplex Virus (HSV) types 1 and 2 mucocutaneous and genital infections

Varicella-Zoster Virus (VZV) including shingles (herpes zoster) and chickenpox

Prophylaxis in immunocompromised patients

HSV encephalitis

Neonatal herpes

5. Pharmacokinetics

Parameter

Oral Acyclovir

IV Acyclovir

Bioavailability

1020%

100%

Peak Plasma (Tmax)

1.52 hours

Rapid

Half-life (t)

2.53.3 hours (normal renal function)

Protein Binding

933%

Metabolism

Minimal (mostly excreted unchanged)

Excretion

Renal (glomerular filtration and tubular secretion)


6. Dosage Forms

Oral tablets/capsules: 200 mg, 400 mg, 800 mg

Oral suspension: 200 mg/5 mL

Topical cream/ointment: 5%

IV formulation: 25 mg/mL or 50 mg/mL (Acyclovir Sodium)

7. Adverse Effects

Common: Nausea, diarrhea, headache, malaise

Serious: Nephrotoxicity (especially IV), neurotoxicity (tremors, seizures), crystalline nephropathy (rare)

8. Drug Interactions

Probenecid: May increase acyclovir serum levels

Other nephrotoxic agents: Increased risk of renal impairment

Zidovudine: May increase CNS side effects

9. Contraindications & Precautions

Contraindications: Hypersensitivity to acyclovir or valacyclovir

Caution in: Renal impairment (dose adjustment required), elderly, dehydration

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