
We are offering high quality Acyclovir.We are known for manufacturing, exporting, distributing, trading and supplying Acyclovir in Gujarat, India. Further, this is safely packaged by our professionals in diverse packaging options that maintain its purity and effectiveness.
Shreeji Pharma International is leading Manufacturer, Exporter, Distributor, and Supplier of Bisacodyl Acyclovir in Gujarat. India. Shreeji Pharma International manufacturing & gmp; supplying all products under GMP site with all types of regulatory supports.
Shreeji Pharma International is the largest manufacturer, Exporter and supplier ofAcyclovir nowadays Shreeji Pharma International is one of the leading manufacturer and exporter, who is manufacturing Acyclovir as well as Intermediates of Acyclovir.
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Shreeji Pharma International currently export Bisacodyl to countries likeGulf Countries, South East Asia countries, African Countries, CIS Countries, LATAM countries, Central American Countries and in European countries.
Acyclovir Technical Description
1. General Information
Generic Name: Acyclovir
Brand Names: Zovirax, Sitavig, Acyclovir Sodium (for injection)
Drug Class: Antiviral (Antiherpetic)
ATC Code: J05AB01
Molecular Formula: CHNO
Molecular Weight: 225.21 g/mol
CAS Number: 59277-89-3
Chemical Structure:
Acyclovir is a synthetic purine nucleoside analog structurally related to guanine.
2. Chemical Structure & Properties
IUPAC Name:
2-amino-1,9-dihydro-9-[(2-hydroxyethoxy)methyl]-6H-purin-6-one
LogP (Partition Coefficient): -1.56
Solubility:
Water: Slightly soluble (~1.2 mg/mL at 25C)
pKa: ~2.27 (acidic), ~9.25 (basic)
Appearance: White crystalline powder
3. Mechanism of Action
Acyclovir is selectively phosphorylated by viral thymidine kinase to acyclovir monophosphate, which is then converted by host enzymes to the active acyclovir triphosphate. This compound inhibits viral DNA polymerase and incorporates into viral DNA, leading to chain termination during DNA replication.
4. Indications
Herpes Simplex Virus (HSV) types 1 and 2 mucocutaneous and genital infections
Varicella-Zoster Virus (VZV) including shingles (herpes zoster) and chickenpox
Prophylaxis in immunocompromised patients
HSV encephalitis
Neonatal herpes
5. Pharmacokinetics
Parameter |
Oral Acyclovir |
IV Acyclovir |
Bioavailability |
1020% |
100% |
Peak Plasma (Tmax) |
1.52 hours |
Rapid |
Half-life (t) |
2.53.3 hours (normal renal function) |
|
Protein Binding |
933% |
|
Metabolism |
Minimal (mostly excreted unchanged) |
|
Excretion |
Renal (glomerular filtration and tubular secretion) |
6. Dosage Forms
Oral tablets/capsules: 200 mg, 400 mg, 800 mg
Oral suspension: 200 mg/5 mL
Topical cream/ointment: 5%
IV formulation: 25 mg/mL or 50 mg/mL (Acyclovir Sodium)
7. Adverse Effects
Common: Nausea, diarrhea, headache, malaise
Serious: Nephrotoxicity (especially IV), neurotoxicity (tremors, seizures), crystalline nephropathy (rare)
8. Drug Interactions
Probenecid: May increase acyclovir serum levels
Other nephrotoxic agents: Increased risk of renal impairment
Zidovudine: May increase CNS side effects
9. Contraindications & Precautions
Contraindications: Hypersensitivity to acyclovir or valacyclovir
Caution in: Renal impairment (dose adjustment required), elderly, dehydration
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