- Amcinonide Properties:
- Molar mass: 502.572 g/mol
- CAS ID: 51022-69-6
- ChemSpider ID: 392009
- ChEMBL Id: 1200732
- Introduction of product:
Introduction. Amcinonide is a topical corticosteroid, for reviews, see Hisa et al (1993) Rivara et al (1989) Guin (1984), prescribed for the relief of inflammatory and itchy symptoms of skin disorders that are responsive to corticosteroid treatment.
- How does it work:
Amcinonide is used to treat swelling and itching of the skin, caused by certain skin conditions, such psoriasis and eczema. It works by reducing inflammation or swelling of the skin. This medication may be available under multiple brand names and/or in several different forms.
- Applications. Or where it is used:
Amcinonide topical is used to help relieve redness, itching, swelling, or other discomfort caused by skin conditions. This medicine is a corticosteroid (cortisone-like medicine or steroid).
- How to use:
Apply a thin film of the medication to the affected area and gently rub in, usually 2-3 times daily or as directed by your doctor. Do not cover, bandage, or wrap the area unless directed to do so by your doctor. If used in the diaper area on an infant, do not use tight-fitting diapers or plastic pants.
- Dosage of usage:
1. Patients/caregivers should be instructed to use the minimum quantity of CYCLOCORT® for the shortest duration of time necessary to achieve the desired therapeutic benefit because of the potential for corticosteroids to suppress the hypothalamic-pituitary-adrenal (HPA) axis and cause skin atrophy (See WARNINGS AND PRECAUTIONS).
2. If the condition worsens or does not improve within 2 weeks, treatment and diagnosis should be re-evaluated.
3. Use in pediatric patients is not recommended. Pediatric patients are more likely to develop local and systemic toxicity from equivalent doses of topical corticosteroids because of their larger skin surface to body weight ratios.
4. Geriatric patients may be more susceptible to percutaneous absorption and the potential effects of systemic absorption. The greater frequency of decreased hepatic or renal function in the elderly may delay elimination if systemic absorption occurs.
- Side effects:
The following adverse reactions are reported when topical corticosteroids are used as recommended. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish causal relationship to drug exposure.
1. Endocrine Disorders: Hypothalamic-pituitary adrenal (HPA) axis suppression, cushingoid features (e.g. moon face, central obesity), delayed weight gain/growth retardation in children, osteoporosis, hyperglycemia/glucosuria, hypertension, increased weight/obesity, decreased endogenous cortisol levels, steroid withdrawal syndrome
2. Eye Disorders: glaucoma, cataract subcapsular
3. Gastrointestinal Disorders: upper abdominal pain
4. General Disorders And Administration Site Conditions: Application site irritation/pain.
5. Immune System Disorders: Decreased glucose tolerance has also been reported
6. Skin And Subcutaneous Tissue Disorders: skin striae, skin atrophy, telangiectasia, purpura-like bleeding, acne, dermatitis, hypertrichosis, skin depigmentation, erythema, burning sensation, pruritus, eczema, dryness, itching, local irritation, atrophy of the subcutaneous tissues, pustules, miliaria, folliculitis, pyoderma, allergic contact dermatitis, acneiform eruptions, perioral dermatitis, rash, urticaria, pustular psoriasis, skin wrinkling, alopecia, trichorrhexis, skin infection.
- Warnings and precautions while using this product
Before using amcinonide, tell your doctor or pharmacist if you are allergic to it; or to other corticosteroids or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before using this medication, tell your doctor or pharmacist your medical history, especially of: poor blood circulation, immune system problems.
Do not use if there is an infection or sore present in the area to be treated.
Rarely, using corticosteroid medications for a long time or over large areas of skin can make it more difficult for your body to respond to physical stress. Therefore, before having surgery or emergency treatment, or if you get a serious illness/injury, tell your doctor or dentist that you are using this medication or have used this medication within the past few months.
Though it is unlikely, this medication may temporarily slow down a child's growth if used for a long time. See the doctor regularly so your child's height can be checked.