Betamethasone Dipropionate

Product Description

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Betamethasone Dipropionate Powder Technical Data

Generic Name: Betamethasone Dipropionate
Chemical Structure:

Molecular Formula: C28H37FO7

Molecular Weight: 504.6 g/mol

CAS Number: 5593-20-4

Description

Betamethasone Dipropionate is a synthetic corticosteroid, a potent anti-inflammatory agent used for the treatment of various dermatological conditions. The powder form of Betamethasone Dipropionate is primarily designed for topical application. This formulation allows for controlled release and localized effects on the skin without systemic absorption. It is known for its ability to reduce inflammation, itching, and redness associated with skin conditions.

In the powder form, Betamethasone Dipropionate is typically mixed with excipients to ensure stability, ease of application, and efficacy.

Physical Properties

Appearance: White to off-white powder.

Solubility: Poorly soluble in water; soluble in organic solvents like alcohol, chloroform, and acetone.

Melting Point: 228230C

pH: The pH of the suspension or powder when reconstituted (if applicable) typically ranges from 4.5 to 5.5, suitable for skin application.

Pharmacological Class

Class: Corticosteroids (Topical)

Mechanism of Action: Betamethasone Dipropionate exerts its therapeutic effects by inhibiting the release of pro-inflammatory cytokines and other inflammatory mediators in the body. It also stabilizes lysosomal membranes and inhibits the action of phospholipase A2, thereby reducing inflammation and suppressing the immune response.

Indications

Primary Use:
Betamethasone Dipropionate powder is primarily indicated for inflammatory skin disorders, including:Eczema (atopic dermatitis),Psoriasis,Contact dermatitis,Insect bites or stings,Allergic skin reactions

Secondary Use:For managing rashes, dermatitis, or conditions causing redness and swelling on the skin.

Dosage Form

Formulation: Powder intended for topical use.

Strength: Typically, Betamethasone Dipropionate powder contains approximately 0.05% of the active ingredient, though formulations may vary.

Application:

Topical Application: The powder is applied directly to the affected area after cleaning and drying the skin. The recommended frequency is usually 1-2 times daily depending on the severity of the condition.

Excipients (Commonly Present in Formulations)

Excipients may vary between different brands or formulations of Betamethasone Dipropionate powder. Common excipients can include:

Talc: To help with smooth application and aid in drying.

Starch or Silica: Often used to stabilize the powder.

Magnesium Stearate: To improve powder flowability and consistency.

Pharmacokinetics

Absorption: When applied topically, Betamethasone Dipropionate has minimal systemic absorption under normal use. However, excessive use or application to large areas of skin can lead to absorption through the skin, potentially causing systemic effects such as adrenal suppression.

Metabolism: It is primarily metabolized in the liver to inactive metabolites.

Excretion: Metabolites are primarily excreted via the urine.

Side EffectsCommon side effects associated with Betamethasone Dipropionate powder include:

Local skin reactions: Burning, itching, or irritation at the site of application.

Skin thinning: Prolonged use of corticosteroids can lead to skin atrophy.

Stretch marks: Prolonged application may cause striae (stretch marks).

Dryness or peeling: Overuse or incorrect use may cause skin drying.

Less common systemic side effects from prolonged use include:

Cushings syndrome: Due to systemic absorption.

Adrenal suppression: Occurs with long-term use.

Properties:

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Warnings and precautions while using this product