Digoxin API

Product Description

We are offering high quality of Digoxin. We are known for manufacturing, exporting, Distributing, trading and supplying Digoxin in Gujarat, India. Further, this is safely Packaged by our professionals in diverse packaging options that maintain its purity and Effectiveness.

Shreeji Pharma International is leading Manufacturer, Exporter, Distributor, and Supplier of Digoxin in Gujarat. India. Shreeji Pharma International manufacturing & supplying all products under GMP site with all types of regulatory supports.

Shreeji Pharma International is the largest manufacturer, Exporter and supplier of Digoxin Nowadays Shreeji Pharma International is one of the leading manufacturer and exporter, who is manufacturing Cevimeline HCL as well as Intermediates of Digoxin.

Shreeji Pharma International is exporter, supplier, distributor and manufacturers of the Active Pharmaceuticals Ingredients in many countries for many years. Shreeji Pharma International currently export Digoxin to countries like Gulf Countries, South East Asia countries, African Countries, CIS Countries, LATAMcountries, Central American Countries and in European countries

• Name: Digoxin
• Form: Fine powder (pharmaceutical raw material)
• Molecular Formula: C41H64O14
• Molecular Weight: 780.94 g/mol
• CAS Number: 20830-75-5
• Class: Cardiac glycoside

Physical Appearance:

• Odor: Odorless
• Taste: Bitter
• Solubility:Soluble in alcohol, chloroform, and pyridine Sparingly soluble in water
• Melting Point: Approximately 230C (with decomposition)
• Assay (by HPLC): 98.0% (varies slightly by supplier or pharmacopeia)
• Moisture Content: <5% (by Karl Fischer titration or loss on drying)
• Residue on Ignition: <0.1%
• Heavy Metals: <10 ppm
• Category: Cardiotonic agent
• Mechanism: Inhibits Na/K-ATPase, increasing intracellular calcium concentration, improving myocardial contractility.

Use and Applications:

• Primary Use: Treatment of congestive heart failure (CHF) and atrial fibrillation
• Formulated Into: Tablets, oral solutions, injectables
• Temperature: Store below 25C (77F)
• Conditions: Protect from light and moisture
• Container: Airtight, light-resistant container

Common Side Effects: Nausea, vomiting,Loss of appetite, Diarrhea,Fatigue or weakness, Dizziness, Headache,Visual disturbances (e.g., blurred vision, yellow or green vision, halos around lights),Bradycardia (slow heart rate)

Warnings & Precautions

• Narrow Therapeutic Index : Requires monitoring of blood levels. Therapeutic range: ~0.5 to 2 ng/mL (varies by clinical situation).
• Renal Impairment: Digoxin is primarily excreted by the kidneys. : Dosage must be adjusted in patients with renal dysfunction to prevent toxicity.
• Electrolyte Imbalance: Hypokalemia, hypomagnesemia, and hypercalcemia increase the risk of toxicity. Avoid or monitor closely if on diuretics or corticosteroids.
• Pre-existing Heart Conditions: Use with caution in sick sinus syndrome, AV block, or ventricular fibrillation unless a pacemaker is in place.
• Pregnancy & Breastfeeding: Use only if clearly needed; it crosses the placenta.Monitor nursing infants for signs of toxicity.