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Diminazene Diaceturate is a veterinary drug primarily used for the treatment of protozoal infections in animals, especially in cattle, sheep, and dogs. It's often employed to treat diseases caused by Trypanosoma species (like African sleeping sickness and Nagana in livestock) and certain other protozoal infections.
Description:
Chemical Name: Diminazene diaceturate
Molecular Formula: C12H12N6C4H6O4
CAS Number: 364-88-7
Appearance: It typically appears as a white to off-white crystalline powder.
Uses:
Trypanosomiasis: For treatment of trypanosomal infections, including diseases like African trypanosomiasis (sleeping sickness) in animals and Nagana in livestock.
Babesiosis: It is sometimes used in treating Babesia infections in animals.
Theileriosis: The drug can be used to treat Theileria infections, another protozoal disease affecting livestock.
Dosage and Administration:
Diminazene diaceturate is typically administered via intramuscular injection, but the specific dosage varies based on the species and condition being treated. For example:
In cattle, the dosage is usually about 3.5 mg per kg body weight.
In sheep, it might be around 3-4 mg per kg.
Side Effects:
Toxicity: Overdose or incorrect administration can lead to toxicity, which can manifest as signs of neurological impairment, gastrointestinal disturbances, or cardiovascular issues.
Local reactions: Injection site reactions may occur.
Hypersensitivity: Allergic reactions, though rare, can happen in some animals.
Precautions:
Ensure correct dosing to avoid toxicity, especially in animals with preexisting health conditions.
Care should be taken in pregnant or lactating animals, though its often used cautiously in such cases.
Avoid use in animals with kidney or liver impairment, as these conditions can increase the likelihood of adverse effects.
Storage:
Store in a cool, dry place, away from direct sunlight.
Protect from moisture to maintain the stability of the powder.
Always consult a veterinarian for proper diagnosis, dosage recommendations, and treatment plans specific to the animal and condition being treated.
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