DOXAZOSIN MESILATE

DOXAZOSIN MESILATE About

We are offering high quality of Doxazosin mesylate. We are known for manufacturing,exporting, distributing, trading and supplying Doxazosin mesylate in Gujarat, India. Further, this is safely packaged by our professionals in diverse packaging options that maintain its purity and effectiveness.

Shreeji Pharma International is leading Manufacturer, Exporter, Distributor, and Supplier of Doxazosin mesylate in Gujarat. India. Shreeji Pharma International manufacturing & supplying all products under GMP site with all types of regulatory supports. Shreeji Pharma International is the largest manufacturer, Exporter and supplier

of Doxazosin mesylate Nowadays Shreeji Pharma International is one of the leading manufacturer and exporter, who is manufacturing Doxazosin mesylate as well as Intermediates of Doxazosin mesylate. Shreeji Pharma International is exporter, supplier, distributor and manufacturers of the Active Pharmaceuticals Ingredients in many countries for many years.

Shreeji Pharma International currently export Doxazosin mesylate to countries like Gulf Countries, South East Asia countries, African Countries, CIS Countries, LATAMcountries, Central American Countries and in European countries

• Chemical Name: Doxazosin mesylate
• Other Names: Doxazosin methane sulfonate; Cardura (brand name)
• Molecular Formula: C23H25N5O5CH4O3S
• Molecular Weight: 547.6 g/mol (mesylate salt)
• CAS Number: 77883-43-3 (mesylate salt)
• Appearance: White to off-white crystalline powder
• Solubility: Freely soluble in dimethyl sulfoxide (DMSO) and methanol; slightly soluble in water
• Storage Conditions: Store at 2C to 8C (refrigerated); protect from light and moisture

Pharmacological Classification:

• Drug Class: Alpha-1 adrenergic blocker (selective 1-antagonist)
• Therapeutic Use: Antihypertensive agent; used in the treatment of:
• High blood pressure (hypertension)
• Benign prostatic hyperplasia (BPH)

Mechanism of Action:Doxazosin mesylate selectively inhibits postsynaptic alpha-1 adrenergic receptors, resulting in vasodilation of arteries and veins. This reduces peripheral vascular resistance and lowers blood pressure. In BPH, it relaxes the smooth muscles in the bladder neck and prostate, improving urine flow.

Applications:

• Used in the formulation of oral tablets (typically 1 mg, 2 mg, 4 mg, and 8 mg)
• API for manufacturing antihypertensive and BPH medications

Side Effects:

• Dizziness, headache
• Fatigue, edema
• Orthostatic hypotension
• Nasal congestion
• Rare: Priapism, hepatic dysfunction

Precautions & Warnings:

• First-dose phenomenon: Risk of severe hypotension; start with a low dose
• Use cautiously in patients with liver impairment
• May cause dizzinessadvise caution when operating machinery
• Monitor blood pressure regularly
• Avoid alcohol and other hypotensive agents that can potentiate effects