Letro zole Powder

Product Description

We are offering high quality of Letrozole. We are known for manufacturing, exporting,

Distributing, trading and supplying Letrozole in Gujarat, India. Further, this is safely

Packaged by our professionals in diverse packaging options that maintain its purity and

Effectiveness.

Shreeji Pharma International is leading Manufacturer, Exporter, Distributor, and Supplier of Letrozole in Gujarat. India. Shreeji Pharma International manufacturing & supplying all Products under GMP site with all types of regulatory supports.

Shreeji Pharma International is the largest manufacturer, Exporter and supplier of Letrozole Nowadays Shreeji Pharma International is one of the leading manufacturer and exporter, who is manufacturing Letrozole as well as Intermediates of Letrozole.

Shreeji Pharma International is exporter, supplier, distributor and manufacturers of the Active Pharmaceuticals Ingredients in many countries for many years.

Shreeji Pharma International currently export Letrozole to countries like Gulf Countries, South East Asia countries, African Countries, CIS Countries, LATAMcountries, Central American Countries and in European countries

• Product Name: Letrozol
• Chemical Name:4,4'-(1H-1,2,4-Triazol-1-ylmethylene)dibenzonitrile
• Molecular Formula:CHN
• Molecular Weight:285.31 g/mol
• CAS Number:112809-51-5 
• Appearance:White to off-white crystalline powder

Solubility:

• Slightly soluble in water
• Freely soluble in methanol, ethanol, and acetone
• Practically insoluble in non-polar solvents like hexane

• Melting Point:Letrozole has a melting point in the range of approximately 184185C.
• Purity (Assay):Typically 98% (depending on the grade and manufacturer specifications)
• Pharmacological Class:Non-steroidal aromatase inhibitor
• Usage/Application:Letrozole is primarily used for Treatment of hormone receptor-positive breast cancer in postmenopausal women Off-label use in female infertility treatment to induce ovulation

Mechanism of Action:Letrozole works by inhibiting the aromatase enzyme, which converts androgens into estrogens. Lowering estrogen levels helps reduce the growth stimulus for estrogen receptor-positive breast cancers.

Storage Conditions:

• Store in a tightly closed container
• Keep in a cool, dry place
• Protect from light and moisture
• Recommended storage temperature: 2C to 8C (refrigerated), or as per supplier's guidance

Letrozole is a non-steroidal aromatase inhibitor primarily used in the treatment of hormone receptor-positive breast cancer in postmenopausal women. In pharmaceutical manufacturing, Letrozole powder is the active pharmaceutical ingredient (API) used for formulation into tablets.

Side Effects of Letrozole Powder (API Formulated Drug Use)

Common side effects:Hot flashes,Fatigue,Dizziness,Increased sweating,Headache,Joint or muscle pain (arthralgia),Nausea,Hair thinning.

Less common but serious side effects:Osteoporosis or bone fractures (due to estrogen depletion)

High cholesterol levels,Depression or mood changes,Visual disturbances,Swelling of arms or legs

Shortness of breath

Warnings and Precautions

• Bone Health Letrozole can reduce estrogen levels, leading to decreased bone mineral density and an increased risk of fractures. Bone density monitoring is recommended for long-term users.
• Cardiovascular Risk Use cautiously in patients with pre-existing heart conditions or hyperlipidemia, as it may increase cholesterol levels.

Pregnancy & Lactation

• Contraindicated in pregnancy: Letrozole may cause fetal harm.
• Not recommended during breastfeeding.: Hepatic Impairment
• Use with caution in patients with moderate to severe liver disease.
• CNS Effects: May cause dizziness and fatigue; caution when operating machinery or driving.
• Allergic Reactions: Hypersensitivity to Letrozole or any of its components can cause rash, itching, or swelling.

Additional Advice

• Regular monitoring of bone density, lipid profile, and liver function may be needed during prolonged therapy.
• Patients should avoid pregnancy during treatment and use effective contraception.