Meropenem Sodium

About Meropenem Sodium

We are offering high quality of Meropenem Sodium  We are known for manufacturing, exporting, distributing, trading and supplying Meropenem Sodium  in Gujarat, India. Further, this is safely packaged by our professionals in diverse packaging options that maintain its purity and effectiveness. Shreeji Pharma International is leading Manufacturer, Exporter, Distributor, and Supplier Meropenem Sodium  in Gujarat. India. Shreeji Pharma International manufacturing & gmp; supplying all products under GMP site with all types of regulatory supports. Shreeji Pharma International is the largest manufacturer, Exporter and supplier of Meropenem Sodium  .Nowadays Shreeji Pharma International is one of the leading manufacturer and exporter, who is manufacturing Meropenem Sodium  as well as Intermediates of Meropenem Sodium  .Shreeji Pharma International is exporter, supplier, distributor and manufacturers of the Active Pharmaceuticals Ingredients in many countries for many years.

Shreeji Pharma International currently export Meropenem Sodium  countries like Gulf Countries, South East Asia countries, African Countries, CIS Countries, LATAM countries, Central American Countries and in European countries.

Meropenem sodium is a broad-spectrum antibiotic used to treat various bacterial infections. It belongs to the class of antibiotics known as carbapenems and is effective against a wide range of Gram-positive, Gram-negative, and anaerobic bacteria.

Key Details:

Mechanism of Action:
Meropenem works by inhibiting bacterial cell wall synthesis. It binds to penicillin-binding proteins (PBPs), disrupting the bacterial cell wall structure, causing bacterial cell death.

Indications:
Meropenem is used to treat serious infections caused by susceptible organisms, such as:

Pneumonia (including hospital-acquired and ventilator-associated pneumonia)

Complicated intra-abdominal infections

Complicated urinary tract infections

Complicated skin and soft tissue infections

Meningitis

Sepsis

Endocarditis

Peritonitis

Administration:
Meropenem is usually administered intravenously (IV), either as a slow injection or infusion. Dosing can depend on the specific infection being treated, but it is typically given every 8 hours.

Side Effects: Common side effects include:

Diarrhea

Nausea

Vomiting

Rash

Elevated liver enzymes

Allergic reactions (rare)

Serious side effects (though less common) can include seizures, severe allergic reactions, or Clostridium difficile-associated diarrhea.

Pharmacokinetics:

Absorption: Since it's given intravenously, meropenem has 100% bioavailability.

Distribution: It is widely distributed in body tissues and fluids, including the lungs, urine, and cerebrospinal fluid (CSF), making it effective for treating infections in these areas.

Metabolism: Minimal metabolism in the liver.

Excretion: It is excreted primarily in the urine, both unchanged and as metabolites.

Contraindications and Precautions:

Meropenem should be used cautiously in patients with a history of seizures, as carbapenems have been associated with an increased risk of seizures.

Caution is also advised in patients with renal impairment since the drug is eliminated via the kidneys.

It should be used with caution in patients who have a history of hypersensitivity to beta-lactam antibiotics (like penicillins and cephalosporins).

Drug Interactions:

Valproic acid: Meropenem can lower blood levels of valproic acid, potentially leading to seizures in patients taking both medications.

Probenecid: When given together, probenecid can increase meropenem blood levels by inhibiting its renal excretion.