Meropenem Sodium

Product Description

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Meropenem sodium is a broad-spectrum antibiotic used to treat various bacterial infections. It belongs to the class of antibiotics known as carbapenems and is effective against a wide range of Gram-positive, Gram-negative, and anaerobic bacteria.

Key Details:

Mechanism of Action:
Meropenem works by inhibiting bacterial cell wall synthesis. It binds to penicillin-binding proteins (PBPs), disrupting the bacterial cell wall structure, causing bacterial cell death.

Indications:
Meropenem is used to treat serious infections caused by susceptible organisms, such as:

Pneumonia (including hospital-acquired and ventilator-associated pneumonia)

Complicated intra-abdominal infections

Complicated urinary tract infections

Complicated skin and soft tissue infections

Meningitis

Sepsis

Endocarditis

Peritonitis

Administration:
Meropenem is usually administered intravenously (IV), either as a slow injection or infusion. Dosing can depend on the specific infection being treated, but it is typically given every 8 hours.

Side Effects: Common side effects include:

Diarrhea

Nausea

Vomiting

Rash

Elevated liver enzymes

Allergic reactions (rare)

Serious side effects (though less common) can include seizures, severe allergic reactions, or Clostridium difficile-associated diarrhea.

Pharmacokinetics:

Absorption: Since it's given intravenously, meropenem has 100% bioavailability.

Distribution: It is widely distributed in body tissues and fluids, including the lungs, urine, and cerebrospinal fluid (CSF), making it effective for treating infections in these areas.

Metabolism: Minimal metabolism in the liver.

Excretion: It is excreted primarily in the urine, both unchanged and as metabolites.

Contraindications and Precautions:

Meropenem should be used cautiously in patients with a history of seizures, as carbapenems have been associated with an increased risk of seizures.

Caution is also advised in patients with renal impairment since the drug is eliminated via the kidneys.

It should be used with caution in patients who have a history of hypersensitivity to beta-lactam antibiotics (like penicillins and cephalosporins).

Drug Interactions:

Valproic acid: Meropenem can lower blood levels of valproic acid, potentially leading to seizures in patients taking both medications.

Probenecid: When given together, probenecid can increase meropenem blood levels by inhibiting its renal excretion.