Toldimfos Sodium

Product Description

We are offering high quality of Toldimfos sodium . We are known for manufacturing, exporting, distributing, trading and supplying Toldimfos sodium   in in Gujarat, India. Further, this is safely packaged by our professionals in diverse packaging options that maintain its purity and effectiveness.

Shreeji Pharma International is leading Manufacturer, Exporter, Distributor, and Supplier Toldimfos sodium   in Gujarat. India. Shreeji Pharma International manufacturing & gmp; supplying all products under GMP site with all types of regulatory supports.

Shreeji Pharma International is the largest manufacturer, Exporter and supplier of Toldimfos sodium . Nowadays Shreeji Pharma International is one of the leading manufacturer and exporter, who is manufacturing Toldimfos sodium  as well as Intermediates of Toldimfos sodium .  

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Shreeji Pharma International currently export Toldimfos sodium  to countries like Gulf Countries, South East Asia countries, African Countries, CIS Countries, LATAM countries, Central American Countries and in European countries.

Toldimfos Sodium is a phosphodiesterase (PDE) inhibitor that is used primarily in the treatment of chronic obstructive pulmonary disease (COPD) and other pulmonary diseases, particularly for managing symptoms of bronchospasm. It acts by increasing the levels of cyclic adenosine monophosphate (cAMP) within smooth muscle cells, which leads to bronchodilation (widening of the airways), helping improve airflow in the lungs.

Description & Properties:

Chemical Name: Sodium 3-[2-(2,4-dimethylphenyl)-1,3-thiazol-4-yl]-1,3,5-triazine-2,4-diamine

Chemical Formula: C11H14N4SNa

Molecular Weight: 266.32 g/mol

Appearance: White to off-white powder.

Solubility: Soluble in water.

Toldimfos Sodium is typically available in oral tablet or powder form for inhalation.

Mechanism of Action:

Toldimfos Sodium works by inhibiting phosphodiesterase type 4 (PDE4), an enzyme that degrades cyclic adenosine monophosphate (cAMP) in cells. By inhibiting PDE4, Toldimfos increases the levels of cAMP within cells, leading to bronchodilation and reduced inflammation in the airways. This results in eased breathing and decreased symptoms of bronchospasm, a condition where the airways tighten and narrow.

PDE4 Inhibition: By inhibiting PDE4, Toldimfos also reduces the release of inflammatory mediators, improving lung function and reducing airway inflammation.

Uses:

Toldimfos Sodium is primarily used in the management of conditions involving bronchospasm and airway inflammation. Its main uses include:

Chronic Obstructive Pulmonary Disease (COPD):

Used to treat symptoms of COPD, including wheezing, shortness of breath, and chronic cough, by helping to open up airways and reduce inflammation.

Asthma:

Sometimes used in combination with other treatments for asthma to help control symptoms and improve lung function.

Bronchospasm:

Used in conditions that involve spasms of the airway, such as in chronic bronchitis or emphysema, by reducing the frequency and severity of bronchospasms.

Dosage and Administration:

The dosage of Toldimfos Sodium will vary depending on the condition being treated and the individual patient. It is important to follow the instructions provided by the healthcare provider.

Chronic Obstructive Pulmonary Disease (COPD):

For COPD, the typical dose is one 300 mg tablet once a day. However, dosages can vary, so it's crucial to adhere to the prescribed regimen.

Asthma:

In cases where it is used for asthma, the dose might be adjusted based on the severity of the condition and the patients response.

Toldimfos Sodium is typically taken orally, but if used in inhaler form, the patient should follow the specific instructions for proper inhalation technique.

Side Effects:

Toldimfos Sodium can cause a variety of side effects, some of which may be serious. Common and severe side effects include:

Gastrointestinal: Nausea, vomiting, and diarrhea may occur in some patients.

Headache: A common side effect when taking the medication.

Dizziness or lightheadedness.

Fatigue or weakness.

Respiratory: Some patients may experience dry mouth, throat irritation, or coughing when using the inhalation form.

Increased Heart Rate: In rare cases, it may cause tachycardia (increased heart rate).

Allergic Reactions: Rash, itching, or swelling, especially around the face, lips, or throat.

Liver Function: There is a potential for liver enzyme elevations, so liver function tests may be recommended during treatment.

Increased Risk of Infections: As with many drugs that modulate immune responses, there may be an increased risk of respiratory infections or nasal infections.

Precautions:

Liver Disease: Toldimfos Sodium should be used with caution in patients with liver dysfunction. Liver function should be monitored during treatment.

Pregnancy and Lactation: The safety of Toldimfos Sodium during pregnancy or breastfeeding has not been well-established. It should only be used if the potential benefits outweigh the risks.

Kidney Disease: There may be a need for dose adjustments in patients with kidney disease.

Concomitant Medications: Toldimfos may interact with other medications, including other respiratory treatments or PDE inhibitors, and care should be taken to avoid drug interactions.

Contraindications:

Hypersensitivity: Toldimfos Sodium is contraindicated in individuals who have known allergies to the drug or any of its components.

Severe Liver Disease: Contraindicated in patients with severe liver dysfunction or cirrhosis.

Storage:

Storage Conditions: Store at room temperature (2025C or 6877F), away from heat, moisture, and light.

Shelf Life: Keep the medication in its original packaging, tightly closed, and out of reach of children.

Conclusion:

Toldimfos Sodium is an effective PDE4 inhibitor used to treat bronchospasm, chronic obstructive pulmonary disease (COPD), and other respiratory conditions by reducing inflammation and helping to relax the airways. It increases cAMP levels, leading to bronchodilation and better airflow. Like any medication, it carries the risk of side effects, including gastrointestinal disturbances and respiratory infections, and should be used under the supervision of a healthcare provider, especially in patients with liver or kidney disease. Regular monitoring during treatment is essential to ensure safety and efficacy.