Methylprednisolone aceponate, also known as methylprednisolone acetate propionate is available under the brands Advantan and Avancort in the market. It is a glucocorticoid and a corticosteroid ester— particularly the C21 acetate diester and C17α propionate of methylprednisolone.
- Description: white crystalline powder
- Solubility: soluble in chloroform, Ethyl acetate
- Identification: The infrared spectrum of the sample is concordant to that of the standard
- Melting Point: 135.4
- Loss on drying : 0.56%
- Assay: 99.1%
- Particle size: complies
How does it work?
There is strong evidence that MPA has the ability to quickly, reliably and highly effectively treat eczematous disorders, with effectiveness equivalent to most reference topical steroids. It also has excellent local and systemic tolerability.
The present invention is related to a procedure for synthesising methyl prednisolone aceponate. As an initial material for its synthesis, methyl prednisolone is used, followed by reaction with propionic acid, cyclic ester hydrolysis with 200-300 mesh G-type silica gel as a catalyst, and finally reaction with acetic acid. This invention produces methyl prednisolone aceponate products that are of high purity, have a low rate of side products, and are simple, mild in reaction conditions, and can easily be used in industrial production.
- Skin thinning
- Appearance of fine blood vessels on the skin surface
- Stretch marks
- Infection of hair follicles
- Excessive unwanted hair growth
- Redness and irritation around the mouth (perioral dermatitis)
- Skin discolouration
Warnings and precautions while using this product
Do not use methylprednisolone if you are allergic to it, prednisone, or if you have any other allergies. It is possible that this product contains inactive ingredients that are harmful to health. If you wish to know more, contact your pharmacist.