Methylprednisolone aceponate (MPA) has been shown to provide rapid, reliable and highly effective treatment of eczematous disorders, with an efficacy comparable to that of most reference topical corticosteroids. It also has excellent local and systemic tolerability.
472.57 Grams (g)
C27H36O7
NMT 1.0%w/w
Cosmetic Grade
Methylprednisolone Aceponate
86401-95-8
soluble in chloroform, ethyl acetate
Powder
Methylprednisolone Aceponate Trade Information
Any indian port
Cash Against Delivery (CAD) Cash on Delivery (COD) Letter of Credit (L/C) Cash in Advance (CID) Cash Advance (CA)
1000 Kilograms Per Month
1 Week
Free samples are available
drum packing
All India
ISO GMP
Product Description
Methylprednisolone aceponate, also known as methylprednisolone acetate propionate is available under the brands Advantan and Avancort in the market. It is a glucocorticoid and a corticosteroid ester particularly the C21 acetate diester and C17 propionate of methylprednisolone.
Properties:
Description: white crystalline powder
Solubility: soluble in chloroform, Ethyl acetate
Identification: The infrared spectrum of the sample is concordant to that of the standard
Melting Point: 135.4
Loss on drying : 0.56%
Assay: 99.1%
Particle size: complies
How does it work?
There is strong evidence that MPA has the ability to quickly, reliably and highly effectively treat eczematous disorders, with effectiveness equivalent to most reference topical steroids. It also has excellent local and systemic tolerability.
Manufacturing process:
The present invention is related to a procedure for synthesising methyl prednisolone aceponate. As an initial material for its synthesis, methyl prednisolone is used, followed by reaction with propionic acid, cyclic ester hydrolysis with 200-300 mesh G-type silica gel as a catalyst, and finally reaction with acetic acid. This invention produces methyl prednisolone aceponate products that are of high purity, have a low rate of side products, and are simple, mild in reaction conditions, and can easily be used in industrial production.
Side effects:
Skin thinning
Appearance of fine blood vessels on the skin surface
Stretch marks
Acne
Infection of hair follicles
Excessive unwanted hair growth
Redness and irritation around the mouth (perioral dermatitis)
Skin discolouration
Warnings and precautions while using this product
Do not use methylprednisolone if you are allergic to it, prednisone, or if you have any other allergies. It is possible that this product contains inactive ingredients that are harmful to health. If you wish to know more, contact your pharmacist.