Nimesulide API powder

Nimesulide API powder About

It is a first generation antihistamine that competes with free histamine for binding at HA-receptor sites. We have carved a niche in the market as a prime organization engaged in offering our clients Nimesulide. It is an antihistamine used to relieve symptoms of allergy, hay fever, and the common cold. This medication works by blocking a certain natural substance called histamine that your body makes during an allergic reaction. Nimesulide helps dry up some body fluids to relieve symptoms such as watery eyes and runny nose.

In the United States, nimesulide is not available, but in other countries, it is widely used to treat acute pain. The NSAID nimesulide has a sulfonanilide structure. A NSAID such as nimesulide inhibits the enzyme cyclo-oxygenase (COX), preventing the formation of pro-inflammatory prostaglandins necessary for pain and inflammation.

Nimesulide Propeties:

• CAS No.: 51803-78-2
• Formula: C₁₃H₁₂N₂O₅S
• Molecular Weight: 308.31
• Synonyms: Aulin;Flogovital;N-(4-Nitro-2-phenoxyphenyl)methanesulfonamide;4'-Nitro-2'-phenoxymethansulfonanilid;Methanesulfonamide,N-(4-nitro-2-phenoxyphenyl)-;4-Nitro-2-phenoxy-methanesulfonanilide;
• EINECS: 257-431-4
• Density: 1.451 g/cm3
• Melting Point: 140-146 C
• Boiling Point: 442 C at 760 mmHg
• Flash Point: 221.1 C
• Appearance: Yellow Needle-Like Crystals
• Risk Codes: 22-36/37/38
• Safety Description: 36-26           
• Transport Information: UN 2811 6

Applications Or where it is used:

Nimesulide is a nonsteroidal anti-inflammatory drug (NSAID) used for pain relief and fever reduction. The drug is approved to treat acute pain, osteoarthritis symptoms, and primary dysmenorrhoea in adolescents and adults older than 12 years.

Manufacturing process:

• Step  I : SIFTING : Using a vibratory sifter fitted with a sieve of size 20, sift Nimesulide and Lactose Monohydrate; collect in IPCs. 
• Step  II : DRY MIXING : Mix dry the sifted materials in the RMG. (mix at slow speed, no chopper for 10 minutes).

How to use:

Nimesulide 100mg Tablet treats pain, inflammation, and fever. Take it with food to prevent nausea. Consult your doctor for dosage and duration. Chronic use can result in serious complications such as stomach bleeding and kidney problems.

Dosage of usage:

Nimesulide will not have any effect if you miss one or two doses. You can safely skip a dose. It's true that some medications won't work if you don't take them on time. Some chemical changes may occur if you miss a dose. You may be advised to take the prescribed medicine as soon as possible if you miss a dose.

Side effects:

Common and serious side effects of nimesulide are as follows:

• Acid or sour stomach
• Stomach discomfort and cramps
• Elevated Liver enzymes
• Blood clotting disorders
• Dizziness
• Skin rash
• Nausea and Vomiting
• Diarrhea

You should seek medical attention immediately if you exhibit any of these symptoms. Anyhow, Nimesulide may cause reactions in your body, so try avoiding it if possible.

In most cases, this medicine has no side effects. Any serious side effects of Nimesulide must be treated immediately.

Warnings and precautions while using this product:

•  Gastrointestinal bleeding: It is advisable to use Nimesulide judiciously because it may cause gut bleeding. Any incident of stomach or gastrointestinal bleeding should be reported promptly to the doctor.
•  Heart Disease: Nimesulide should be used cautiously if you have heart or valve disease. Tell your doctor about any such incident as soon as possible.
• Liver Disease: Mild to severe side effects can occur when taking nimesulide. As a precaution, a doctor should know if the patient has liver abnormalities, whether they are present or in the past.