Ondansetron Api Powder

Product Description

We have been able to attain strong market goodwill as a trusted organization engaged in offering Ondansetron Hydrochloride. It is used as a semi-synthetic macrolide antibiotic. This drug prevents bacteria from growing, by interfering with their protein synthesis. It binds to the subunit 50S of the bacterial ribosome, and thus inhibits the translocation of peptides. Ondansetron Hydrochloride has similar antimicrobial spectrum as erythromycin, but is more effective against certain gram-negative bacteria, particularly legionella pneumophila. It can treat respiratory tract, urinary and soft tissue infections.

Ondansetron API Powder: Detailed Description

Chemical Name: Ondansetron
Chemical Formula: C18H19N3O
Molecular Weight: 293.37 g/mol
CAS Number: 99614-02-5

What is Ondansetron?

Ondansetron is a selective 5-HT3 receptor antagonist used primarily as an antiemetic to prevent nausea and vomiting caused by chemotherapy, radiation therapy, or surgery. It works by blocking serotonin, a natural substance that may cause nausea and vomiting, from binding to 5-HT3 receptors in the brain and gastrointestinal tract.

Physical Characteristics of Ondansetron API Powder

• Appearance: White to off-white crystalline powder

• Solubility: Slightly soluble in water, soluble in methanol and ethanol

• Melting Point: Approximately 181-184C

• Particle Size: Usually micronized or sieved for uniform particle size distribution

• Odor: Odorless or faintly characteristic

Pharmacological Profile

• Mechanism of Action: Ondansetron selectively antagonizes serotonin 5-HT3 receptors located both peripherally on vagal nerve terminals and centrally in the chemoreceptor trigger zone of the brain, thereby preventing the vomiting reflex.

• Bioavailability: High oral bioavailability (about 60%)

• Half-life: Approximately 3-4 hours in healthy adults

Manufacturing and Quality Control

• Purity: High purity (>99%) is required for pharmaceutical use

• Identification Tests: UV spectroscopy, HPLC, and IR spectroscopy to confirm identity and purity

• Impurities: Strict control on residual solvents, heavy metals, and other impurities per pharmacopeial standards (e.g., USP, EP)

• Stability: Stable under recommended storage conditions (cool, dry, away from light)

Applications of Ondansetron API Powder

• Pharmaceutical Formulations: Tablets, oral solutions, injectable formulations

• Indications: Prevention and treatment of nausea and vomiting associated with cancer chemotherapy, radiation therapy, and postoperative conditions

Storage Conditions

• Store in a cool, dry place away from moisture and direct sunlight.

• Typically stored in tightly closed containers to prevent contamination and degradation.