Ornidazole .

About Ornidazole .

It is used in the treatment of bacterial infections and parasitic infections. In this field we are recognized amongst trusted organization engaged in offering Ornidazole. It is an effective medicine to treat infections caused by protozoa and certain strains of anaerobic bacteria. This drug is used to treat infections of the stomach, intestine, urinary tract and genital area. It is also used to prevent possible infections during a surgical procedure. Ornidazole is an antibiotic drug, kills the bacteria and other microorganisms that cause infections by damaging the DNA.

Ornidazole

Class: Nitroimidazole antimicrobial agent
Type: Antiprotozoal and antibacterial agent

Chemical and Pharmacological Information:

• Chemical class: Nitroimidazole derivative, structurally related to metronidazole.

• Mechanism of action: Ornidazole works by entering anaerobic microorganisms (such as protozoa and certain bacteria) and undergoing reduction of its nitro group. This reduction creates reactive intermediates that damage DNA and other critical biomolecules within the pathogen, leading to inhibition of nucleic acid synthesis and ultimately microbial death.

• Spectrum of activity: Active primarily against anaerobic bacteria and certain protozoa including Trichomonas vaginalis, Giardia lamblia, Entamoeba histolytica, and various anaerobic bacterial infections.

Indications:

• Treatment of infections caused by susceptible anaerobic bacteria.

• Protozoal infections such as:

  • Amoebiasis (intestinal and hepatic)

  • Giardiasis

  • Trichomoniasis

• Sometimes used as a part of combination therapy for Helicobacter pylori infection.

• Bacterial vaginosis

• Anaerobic infections of skin, respiratory tract, genitourinary tract, and gastrointestinal tract.

Dosage Forms:

• Oral tablets/capsules

• Intravenous formulations

• Sometimes topical formulations

Dosage:

• Varies depending on indication, severity of infection, and patient factors.

• Typical oral adult dose for protozoal infections: 500 mg twice daily for 5-10 days.

• For bacterial infections, dosing and duration may vary.

Pharmacokinetics:

• Absorption: Well absorbed orally.

• Distribution: Widely distributed in body tissues and fluids.

• Metabolism: Metabolized mainly in the liver.

• Excretion: Primarily renal excretion of metabolites.

Side Effects:

• Common:

  • Gastrointestinal discomfort (nausea, vomiting, abdominal pain)

  • Metallic taste in the mouth

  • Headache

  • Dizziness

• Less common but serious:

  • Peripheral neuropathy with prolonged use

  • Hypersensitivity reactions

  • Seizures (rare)

  • Disulfiram-like reaction with alcohol (flushing, nausea, vomiting)

Contraindications and Precautions:

• Hypersensitivity to nitroimidazoles.

• Use cautiously in patients with central nervous system disorders or hepatic impairment.

• Avoid alcohol during treatment and for at least 48 hours after finishing therapy to prevent disulfiram-like reaction.

• Not recommended during the first trimester of pregnancy unless clearly needed.

• Lactation: Use with caution; limited data on safety.

Drug Interactions:

• Increased anticoagulant effect with warfarin.

• Potential interaction with other drugs metabolized by liver enzymes.

• Alcohol causes disulfiram-like reaction.