Valproic Acid

Product Description

We are offering high quality of Valproic Acid. We are known for manufacturing, exporting, distributing, trading and supplying Valproic Acid in in Gujarat, India. Further, this is safely packaged by our professionals in diverse packaging options that maintain its purity and effectiveness.

Shreeji Pharma International is leading Manufacturer, Exporter, Distributor, and Supplier Valproic Acid in Gujarat. India. Shreeji Pharma International manufacturing & gmp; supplying all products under GMP site with all types of regulatory supports.

Shreeji Pharma International is the largest manufacturer, Exporter and supplier of Valproic Acid. Nowadays Shreeji Pharma International is one of the leading manufacturer and exporter, who is manufacturing Valproic Acid as well as Intermediates of Valproic Acid.

Shreeji Pharma International is exporter, supplier, distributor and manufacturers of the Active Pharmaceuticals Ingredients in many countries for many years.

Shreeji Pharma International currently export Valproic Acid to countries like Gulf Countries, South East Asia countries, African Countries, CIS Countries, LATAM countries, Central American Countries and in European countries.

Valproic Acid (also known as valproate) is a medication primarily used to treat a variety of neurological and psychiatric conditions. It is commonly used as an anticonvulsant, mood stabilizer, and in the treatment of other disorders. Here are the detailed descriptions and information about valproic acid:

General Information:

Chemical Name: 2-Propylpentanoic acid.

Molecular Formula: C8H16O2.

CAS Number: 99-66-1.

Other Names: Valproate, Valproic Acid Sodium, Sodium Valproate (the sodium salt form).

Drug Class: Anticonvulsants, mood stabilizers.

Appearance:

Form: Typically available as tablets, capsules, liquid form, and sometimes as an injectable solution.

New roman, serif = Roman, serif  times= Times White to off-white crystalline powder (in pure form).

Odor: No significant odor.

Uses:

Valproic acid has multiple uses in the treatment of medical conditions, including:

Epilepsy/Seizures:

Used to treat various types of seizures, including generalized seizures, focal seizures, and absence seizures.

Commonly prescribed for epilepsy, especially when other medications are ineffective.

Bipolar Disorder:

Used as a mood stabilizer to manage bipolar disorder, especially in acute manic episodes.

Migraine Prevention:

Sometimes prescribed for preventing migraines, though not as a first-line treatment.

Other Uses:

May be used in the management of schizoaffective disorder or in other off-label treatments, including as part of the treatment for agitation in various conditions.

Mechanism of Action:

Valproic acid works through several mechanisms:

Inhibition of GABA Transaminase: Increases the concentration of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA), which helps to stabilize electrical activity in the brain.

Inhibition of Voltage-Gated Sodium Channels: Reduces abnormal electrical activity in the brain, which is beneficial for seizure control.

Histone Deacetylase Inhibition: May have effects on gene expression related to mood stabilization and seizure management.

Dosage and Administration:

The oral dosage of valproic acid varies based on the condition being treated, the patients age, and individual response to the drug.

Typical Adult Dosage for epilepsy:

Start with 10-15 mg/kg/day, divided into 2-3 doses, and gradually increase as needed.

The usual maintenance dose is 20-60 mg/kg/day.

For bipolar disorder, dosages may range from 750 mg to 3,000 mg per day.

Liquid formulations may be prescribed for easier dose adjustments, especially in children or patients who have difficulty swallowing pills.

Side Effects:

Common side effects include:

Gastrointestinal issues (nausea, vomiting, indigestion, abdominal pain).

Weight gain.

Tremors (especially at higher doses).

Hair loss (alopecia).

Drowsiness or sedation.

Dizziness or lightheadedness.

Liver toxicity: Can cause liver damage, especially in young children or those with preexisting liver conditions.

Serious side effects include:

Pancreatitis (inflammation of the pancreas).

Liver failure (rare but severe, especially in young children).

Severe allergic reactions, including rashes, fever, and swelling of the face or limbs.

Teratogenic effects: It is known to be harmful to a developing fetus and is contraindicated during pregnancy due to a significant risk of birth defects, particularly neural tube defects.

Precautions:

Pregnancy Category D: Valproic acid should be avoided during pregnancy due to the risk of serious birth defects, including spina bifida.

Liver Function: Liver function should be monitored during treatment, as liver toxicity can occur, particularly during the first six months of use.

Pancreatitis: Regular monitoring for signs of pancreatitis is recommended.

Drug Interactions: Valproic acid can interact with other medications, especially those that affect the liver enzymes. It is important to inform the doctor of all other medications being taken, including over-the-counter drugs and supplements.

Safety and Monitoring:

Regular blood tests are often required to monitor liver function, blood cell counts, and drug levels in the body.

Blood levels of valproic acid should be monitored to ensure that they fall within the therapeutic range to minimize side effects and improve efficacy.

Drug Interactions:

Valproic acid may interact with other medications, including:

Anticonvulsants (e.g., carbamazepine, phenytoin), as valproic acid can increase or decrease their levels.

Aspirin and other anticoagulants, as valproic acid may increase the effects of these medications.

Warfarin and other blood thinners, as valproic acid can affect clotting.

Antidepressants and antipsychotics, which may have additive sedative effects when combined with valproic acid.

Storage:

Store at room temperature, away from moisture and light.

Keep medication in a tightly closed container.

Environmental Impact:

No significant environmental concerns are associated with valproic acid use, but proper disposal through a pharmacist or according to local regulations is important.

Conclusion:

Valproic acid is a potent and widely used medication, particularly for controlling seizures and stabilizing mood in bipolar disorder. However, due to its potential for serious side effects and interactions, it must be prescribed and monitored by a healthcare professional.