Dexamethasone Product Name : DEXAMETHASONE Molecular Formula : C22H29FO5 Molecular Weight : 392.46 Synonyms : Pregna-1,4-diene-3,20-dione, 9-Fluoro-11,17,21-tri-hydroxy-16-methyl-, (11áµ, 16α)- CAS No :50-02-2 r. No.TestSpecifications1DescriptionWhite to practically white, odorless, crystalline powder.2SolubilitySparingly soluble in acetone, in alcohol, in dioxane and in methanol; slightly soluble in chloroform; very slightly soluble in ether; practically insoluble in water.3Identification A) Infrared Absorption B) Ultraviolet Absorption The IR absorption spectrum of the test preparation should exhibit maxima at the same wavelength as that of a similar preparation of Dexamethasone working standard. Absorptivities at 239 nm, on dried basis should not differ by more than 3.0% 4Specific RotationBetween +72 ° and +80°5Loss on DryingNot more than 0.5% of its weight.6Residue on IgnitionNot more than 0.2% from 250mg7Chromatographic Purity (By HPLC, % w/w) • Individual Impurity • Total ImpurityNot more than 1.0% Not more than 2.0%8Assay (ODB)Between 97.0% and 102.0% |