Diphenhydramine Hydrochloride Powder

Product Description

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Diphenhydramine Hydrochloride is an antihistamine commonly used to relieve symptoms of allergy, hay fever, and the common cold. It is also used for its sedative properties and to treat motion sickness, nausea, and insomnia. As a powder, it is typically used as an active ingredient in medications that are then formulated into tablets, capsules, syrups, and injectables.

Description:

Chemical Name: 2-(Diphenylmethoxy)-N,N-dimethylethanamine hydrochloride

Molecular Formula: C17H21NOHCl

CAS Number: 147-24-0

Appearance: Diphenhydramine hydrochloride appears as a white, crystalline powder.

Solubility: It is soluble in water and alcohol, making it suitable for formulation in liquid preparations.

Uses:

Allergy Relief: It is commonly used to relieve symptoms of hay fever, allergic rhinitis, and other allergic conditions such as sneezing, runny nose, and itching.

Motion Sickness: It helps prevent and treat nausea, vomiting, and dizziness caused by motion sickness.

Insomnia: Due to its sedative properties, it is sometimes used as a short-term sleep aid.

Cough Suppressant: It may be used to relieve cough associated with the common cold or other respiratory infections.

Antiemetic: It is effective in preventing nausea and vomiting, often used in combination with other treatments for conditions like chemotherapy-induced nausea.

Dosage and Administration:

Diphenhydramine hydrochloride in powder form is typically reconstituted into a solution for injection or liquid medication.

The oral dosage varies depending on the product form (tablet, liquid, etc.). Common adult doses for oral use might be:

25-50 mg every 4-6 hours as needed.

Maximum 300 mg per day.

For children, dosing depends on age and weight, and should always be guided by a healthcare provider.

For injection, the typical intravenous (IV) or intramuscular (IM) dose is around 10-50 mg, depending on the condition being treated.

Side Effects:

Common side effects of diphenhydramine hydrochloride include:

Drowsiness (sedation)

Dizziness

Dry mouth, nose, or throat

Blurred vision

Constipation

Urinary retention (difficulty urinating)

More serious but rare side effects may include:

Allergic reactions (rash, itching, swelling)

Severe drowsiness, confusion, or hallucinations (especially in high doses)

Heart-related issues (fast or irregular heartbeats)

Contraindications and Cautions:

Hypersensitivity: Should not be used by individuals allergic to diphenhydramine or similar antihistamines.

Pregnancy and breastfeeding: It is categorized as a Category B drug for pregnancy, meaning it is generally considered safe, but should be used under the guidance of a healthcare provider.

Glaucoma: People with glaucoma should avoid using it, as it may increase intraocular pressure.

Asthma or chronic lung disease: Use with caution.

Elderly: Older adults may be more sensitive to the sedative effects.

Storage:

Storage conditions: Diphenhydramine hydrochloride powder should be stored in a cool, dry place, away from direct light and moisture, to maintain its stability and potency.