08045479576
08045479576
Nikethamide Api Powder
4500.0 INR/Kilograms
Product Details:
- Loss on Drying The Loss on Drying (LOD) for Nikethamide is typically 0.5% when tested under standard drying conditions. This ensures minimal moisture content, maintaining its stability and effectiveness.
- HS Code 29333990
- Smell Other
- Solubility Soluble in water, ethanol, and other organic solvents
- Molecular Weight 178.23 Grams (g)
- Boiling point 120-125 C at 0.7 mmHg
- Heavy Metal (%) The heavy metal content in Nikethamide is typically 0.001% (10 ppm) as per pharmaceutical-grade and regulatory standards. This ensures safety and compliance with pharmacopeial limits.
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Nikethamide Api Powder Price And Quantity
- 25 Kilograms
- 4500.0 INR/Kilograms
Nikethamide Api Powder Product Specifications
- Powder
- Room Temperature
- 68-72 C
- 59-26-7
- 98.0%
- C H N O
- Bitter
- Medicine Grade
- 5 Years
- The pH level of Nikethamide depends on its formulation: Aqueous solution (Nikethamide dissolved in water): Typically neutral to slightly acidic (pH ~6 7). Injectable solutions (historically used): Often adjusted to physiological pH (~7.0 7.4) for compatibility with the body.
- The particle size of Nikethamide depends on its formulation and processing: Pure crystalline form: Typically ranges from micron-sized to sub-millimeter-sized crystals. Pharmaceutical-grade powder: Often micronized for better dissolution, with particle sizes in the range of 10 100 micrometers ( m). Injectable formulations (historically used): Dissolved in solution, so particle size is not relevant.
- O C5H4N C N(C2H5)2
- The heavy metal content in Nikethamide is typically 0.001% (10 ppm) as per pharmaceutical-grade and regulatory standards. This ensures safety and compliance with pharmacopeial limits.
- Coramine
- 120-125 C at 0.7 mmHg
- 200-418-5
- Nikethamide has actions similar to doxapram hydrochloride and was formerly given intravenously, intramuscularly, subcutaneously, or orally for the treatment of overdose due to nervous system depressants, such as morphine, barbiturates and anticholinesterases [1 4] and in patients with chronic respiratory acidosis [5].
- Other
- Clear, colorless to pale yellow liquid (in solution) or white crystalline powder (solid form)
- Nikethamide
- The Loss on Drying (LOD) for Nikethamide is typically 0.5% when tested under standard drying conditions. This ensures minimal moisture content, maintaining its stability and effectiveness.
- 178.23 Grams (g)
- Soluble in water, ethanol, and other organic solvents
- Other
- 29333990
Nikethamide Api Powder Trade Information
- INDIA
- Cash Advance (CA) Cash in Advance (CID) Days after Acceptance (DA) Letter of Credit at Sight (Sight L/C) Letter of Credit (L/C)
- 100 Kilograms Per Day
- 7 Days
- Yes
- Free samples are available
- Drum/Bag packing
- Asia Australia Central America North America South America Eastern Europe Western Europe Middle East Africa
- All India
- WE PROVIDES ALL KIND OF CERTIFICATIONS AS YOU REQUIRED
Product Description
Nikethamide is a central nervous system (CNS) stimulant that primarily acts as a respiratory stimulant. It was previously used in medicine to treat conditions like respiratory depression and to counteract the effects of barbiturate overdose. However, due to its side effects and potential for causing seizures, its medical use has been largely discontinued.
Chemical Information
- IUPAC Name: N,N-Diethyl-3-pyridinecarboxamide
- Molecular Formula: C10H14N2O
- Molecular Weight: 178.23 g/mol
- Appearance: Usually available as a clear solution or tablets in past formulations.
Pharmacology & Mechanism of Action
Nikethamide stimulates the medullary respiratory center, leading to increased respiration rate and depth. It may also have some cardiovascular stimulant effects. Unlike other stimulants such as caffeine or amphetamines, its primary action is on respiratory function rather than general arousal or alertness.
Uses (Historical and Limited Modern Applications)
- Previously used to treat respiratory depression from drug overdose, anesthesia, or other conditions.
- Some use in sports doping (now banned).
- Occasionally used as a stimulant in veterinary medicine.
Side Effects and Risks
- Seizures (especially in high doses)
- Tremors and convulsions
- Nausea and vomiting
- Cardiovascular issues (e.g., hypertension, tachycardia)
- Allergic reactions
Current Status
Nikethamide has been banned or discontinued in most countries due to safety concerns, particularly its potential to cause convulsions and its lack of effectiveness compared to modern alternatives. It is prohibited in competitive sports by the World Anti-Doping Agency (WADA).
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- 311, Atlantis Heights, Sarabhai Main Road, Vadiwadi,Vadodara - 390007, Gujarat, India
- Phone :08045479576
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: nilesh.sheth70
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