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Nikethamide Api Powder

Name: Nikethamide Api Powder
Brand: SHREEJI PHARMA INTERNATIONAL
Price: 4500.0 INR
Availability: InStock

Price 4500.0 INR/ Kilograms

Get a Price/Quote

MOQ : 25 Kilograms

Nikethamide Api Powder Specification

Particle Size
The particle size of Nikethamide depends on its formulation and processing: Pure crystalline form: Typically ranges from micron-sized to sub-millimeter-sized crystals. Pharmaceutical-grade powder: Often micronized for better dissolution, with particle sizes in the range of 10 100 micrometers ( m). Injectable formulations (historically used): Dissolved in solution, so particle size is not relevant.

Solubility
Soluble in water, ethanol, and other organic solvents

Molecular Formula
C H N O

Boiling point
120-125 C at 0.7 mmHg

Shelf Life
5 Years

Ph Level
The pH level of Nikethamide depends on its formulation: Aqueous solution (Nikethamide dissolved in water): Typically neutral to slightly acidic (pH ~6 7). Injectable solutions (historically used): Often adjusted to physiological pH (~7.0 7.4) for compatibility with the body.

Heavy Metal (%)
The heavy metal content in Nikethamide is typically 0.001% (10 ppm) as per pharmaceutical-grade and regulatory standards. This ensures safety and compliance with pharmacopeial limits.

Taste
Bitter

Molecular Weight
178.23 Grams (g)

Storage
Room Temperature

Melting Point
68-72 C

Smell
Other

Structural Formula
O C5H4N C N(C2H5)2

HS Code
29333990

Loss on Drying
The Loss on Drying (LOD) for Nikethamide is typically 0.5% when tested under standard drying conditions. This ensures minimal moisture content, maintaining its stability and effectiveness.

EINECS No
200-418-5

Medicine Name
Coramine

Chemical Name
Nikethamide

CAS No
59-26-7

Type
Other

Grade
Medicine Grade

Usage
Nikethamide has actions similar to doxapram hydrochloride and was formerly given intravenously, intramuscularly, subcutaneously, or orally for the treatment of overdose due to nervous system depressants, such as morphine, barbiturates and anticholinesterases [1 4] and in patients with chronic respiratory acidosis [5].

Purity(%)
98.0%

Appearance
Clear, colorless to pale yellow liquid (in solution) or white crystalline powder (solid form)

Physical Form
Powder

Nikethamide Api Powder Trade Information

Minimum Order Quantity
25 Kilograms

FOB Port
Mumbai Port

Payment Terms
Cash Advance (CA), Cash in Advance (CID), Days after Acceptance (DA), Letter of Credit at Sight (Sight L/C), Letter of Credit (L/C)

Supply Ability
100 Kilograms Per Day

Delivery Time
7 Days

Sample Available
No

Sample Policy
Free samples are available

Packaging Details
Drum Packing

Main Export Market(s)
Asia, Australia, Central America, North America, South America, Eastern Europe, Western Europe, Middle East, Africa

Certifications
WE PROVIDES ALL KIND OF CERTIFICATIONS AS YOU REQUIRED

Nikethamide Api Powder About

Nikethamide is a central nervous system (CNS) stimulant that primarily acts as a respiratory stimulant. It was previously used in medicine to treat conditions like respiratory depression and to counteract the effects of barbiturate overdose. However, due to its side effects and potential for causing seizures, its medical use has been largely discontinued.

Chemical Information

IUPAC Name: N,N-Diethyl-3-pyridinecarboxamide
Molecular Formula: C10H14N2O
Molecular Weight: 178.23 g/mol
Appearance: Usually available as a clear solution or tablets in past formulations.

Pharmacology & Mechanism of Action

Nikethamide stimulates the medullary respiratory center, leading to increased respiration rate and depth. It may also have some cardiovascular stimulant effects. Unlike other stimulants such as caffeine or amphetamines, its primary action is on respiratory function rather than general arousal or alertness.

Uses (Historical and Limited Modern Applications)

Previously used to treat respiratory depression from drug overdose, anesthesia, or other conditions.
Some use in sports doping (now banned).
Occasionally used as a stimulant in veterinary medicine.

Side Effects and Risks

Seizures (especially in high doses)
Tremors and convulsions
Nausea and vomiting
Cardiovascular issues (e.g., hypertension, tachycardia)
Allergic reactions

Current Status

Nikethamide has been banned or discontinued in most countries due to safety concerns, particularly its potential to cause convulsions and its lack of effectiveness compared to modern alternatives. It is prohibited in competitive sports by the World Anti-Doping Agency (WADA).