- CAS No.: 97-77-8
- Formula: C10H20N2S4
- Molecular Weight: 296.52
- Deleted CAS: 11078-22-1|155-01-1
- Synonyms: NCI-C02959;Antiaethan;155-01-1;Contralin;Bis(N,N-diethylthiocarbamoyl) disulfide;Aversan;Thiuram disulfide, tetraethyl-;Averzan;Tiuram;Antaetil;anti-Ethyl;Dupon 4472;Thiuram E;Ekagom DTET;Bis((diethylamino)thioxomethyl) disulfide;tetraethylthiuram disulphide;Anthethyl;tetraethylthioperoxydicarbonic diamide;Ethyldithiourame;Soxinol TET;Tetraetil;Refusal [Netherlands];Abstensil;Bis((diethylamino)thioxomethyl)disulphide;Ethyl thiurad;Antethyl;Tetraethylthiuram;N,N,N,N-Tetraethylthiuram disulphide;Tetraethylthiuran disulfide;Disulfiram [BAN:INN:JAN];Disulfiram (JP14/USP);Ethyl Thiudad;Exhorran;Antetan;N,N,N,N-tetraethylthiuram disulfide;
- EINECS: 202-607-8
- Density: 1.205 g/cm3
- Melting Point: 69-71 °C(lit.)
- Boiling Point: 369.023 °C at 760 mmHg
- Flash Point: 176.979 °C
- Solubility: 0.02 g/100 mL in water
- Appearance: yellow-white crystals or grey powder
Backed with know-how and comprehension in this domain, we are engaged in offering Disulfiram powder. It is carbamate derivative used as an alcohol deterrent. This compound is a relatively nontoxic substance when administered alone, but markedly alters the intermediary metabolism of alcohol. The compound is used in oral drug for treating alcoholism. Alcohol is converted in the body into acetaldehyde by an enzyme called alcohol dehydrogenase. It prevents acetaldehyde dehydrogenase from converting acetaldehyde into acetic acid, leading to a buildup of acetaldehyde levels in the blood.
How does it work?
Disulfiram blocks the breakdown of alcohol in the body. As a result, a toxic alcohol-related compound builds up in the body, which can seriously harm people who drink alcohol while taking this medication. As a result, people are encouraged to avoid alcohol while taking the medication.
Applications Or where it is used
The drug disulfiram is used to treat chronic alcoholism. Alcohol causes unpleasant effects when it is consumed even in small amounts. There may be flushing of the face, weakness, blurry vision, mental confusion, sweating, choking, headaches, nausea, vomiting, chest pain, breathing difficulties, and anxiety.
In order to formulate Disulfiram Tablets, wet granulation will be used. A solution of binder will be prepared by using water. To ensure smooth blend flow and free of any defects in tableting, the formulation will be optimized regarding composition and process.
Dosage of usage
Usual Adult Dose for Alcohol Dependence:
- Initial dose: 500 mg orally once a day continuously for 1 to 2 weeks
- Maintenance dose: 250 mg orally once a day (range: 125 mg to 500 mg once a day)
- Maximum dose: 500 mg once a day
Duration of therapy
Therapy may last months or even years
Disulfiram may cause serious side effects including:
- difficulty breathing
- increased thirst
- rapid weight gain
- neck pain
- blurred vision
- chest pain
- feeling unsteady
- slow heart rate
- weak pulse
- eye pain
- sudden vision loss