Dydroge sterone Powder

Product Description

We are offering high quality of Dydrogesterone. We are known for manufacturing,exporting, distributing, trading and supplying Dydrogesterone in Gujarat, India. Further, this is safely packaged by our professionals in diverse packaging options that maintain its purity and effectiveness.

Shreeji Pharma International is leading Manufacturer, Exporter, Distributor, and Supplier of Dydrogesterone in Gujarat. India. Shreeji Pharma International manufacturing & supplying all products under GMP site with all types of regulatory supports.

Shreeji Pharma International is the largest manufacturer, Exporter and supplier of Dydrogesterone Nowadays Shreeji Pharma International is one of the leading manufacturer and exporter, who is manufacturing Dydrogesterone as well as Intermediates of Dydrogesterone. Shreeji Pharma International is exporter, supplier, distributor and manufacturers of the Active Pharmaceuticals Ingredients in many countries for many years.

Shreeji Pharma International currently export Dydrogesterone to countries like Gulf Countries, South East Asia countries, African Countries, CIS Countries, LATAMcountries, Central American Countries and in European countries

• Name: Dydrogesterone
• Form: White or almost white crystalline powder
• CAS Number: 152-62-5
• Molecular Formula: C21H28O2
• Molecular Weight: 312.45 g/mol
• Solubility: Practically insoluble in water, freely soluble in methylene chloride and acetone
• Melting Point: Approx. 196–200°C

Description:

Dydrogesterone is a synthetic progestogen, structurally related to natural progesterone. It is highly selective for progesterone receptors and does not have androgenic, estrogenic, or glucocorticoid activity. It is primarily used in hormone replacement therapy (HRT), menstrual disorders, and to support early pregnancy where progesterone deficiency is suspected.

In powder form, it is used for the formulation of oral tablets, which are the primary dosage form.

Pharmacological Properties:

• Class: Progestin (Synthetic Hormone)
• Mechanism of Action: Binds to progesterone receptors, mimicking the natural hormone's effects on the endometrium and maintaining pregnancy or regulating the menstrual cycle.
• Bioavailability: High oral bioavailability
• Metabolism: Hepatic (liver metabolism to active metabolites)
• Half-life: Approximately 5–7 hours

Therapeutic Uses:

• Luteal phase support in infertility treatment
• Menstrual irregularities (e.g., amenorrhea, dysmenorrhea)
• Threatened or recurrent miscarriage
• Endometriosis
• Hormone Replacement Therapy (HRT) in combination with estrogen
• Premenstrual syndrome (PMS)

Side Effects:

• Common:Nausea,Headache,Breast tenderness,Fatigue
• Dizziness,Menstrual irregularities (spotting or breakthrough bleeding)
• Less Common but Serious:Allergic reactions (rash, itching, swelling),Jaundice or liver function disturbances
• Mood changes or depression,Migraine exacerbation
• Thromboembolic events (rare)

Warnings:

• Thromboembolic Risk: Though lower than with some other synthetic progestins, there's still a risk—caution in women with a history of thrombosis.
• Liver Disorders: Should be avoided in active liver disease or severe hepatic impairment.
• Undiagnosed Vaginal Bleeding: Do not use until the cause is identified.
• Hormone-sensitive Conditions: Use with caution in individuals with a history of hormone-dependent tumors like breast cancer.
• Pregnancy: Generally safe and often used to support early pregnancy, but only under medical supervision.

Precautions:

• Regular Monitoring: Liver function tests, endometrial evaluation during long-term use with estrogen, and regular gynecological check-ups.
• Breast Cancer Risk: Though dydrogesterone has a better safety profile than older progestins, combined estrogen-progestin HRT can slightly increase breast cancer risk.
• Drug Interactions: CYP3A4 inducers (like rifampin or phenytoin) may reduce effectiveness.
• Not for Use in Children: Not recommended for pediatric use unless specifically indicated and supervised.