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Mebendazole API (Active Pharmaceutical Ingredient) Description
General Information:
Name: Mebendazole
Chemical Formula: C16H13N3O3, Molecular Weight: 295.29 g/mol, IUPAC Name: Methyl 5-benzoyl-2-(2H-benzimidazol-2-yl)-4-methoxycarbamate, CAS Number: 31431-39-7, ATC Code: P02CA01
Pharmacological Classification:
Therapeutic Class: Anthelmintic (Deworming Agent)
Mechanism of Action:
Inhibits microtubule synthesis in intestinal and tissue-dwelling helminths.
Blocks glucose uptake, leading to depletion of glycogen stores and parasite death.
Physical & Chemical Properties:
Appearance: White to slightly yellow crystalline powder
Solubility: Poorly soluble in water; soluble in organic solvents like methanol and ethanol
Melting Point: 288-290C
Indications:
Used for treating various parasitic infections, including:
Ascariasis (Ascaris lumbricoides)
Hookworm infections (Ancylostoma duodenale, Necator americanus)
Trichuriasis (Trichuris trichiura)
Enterobiasis (Enterobius vermicularis)
Strongyloidiasis (Strongyloides stercoralis)
Taeniasis (Tapeworm infections)
Dosage & Administration:
Adults & Children (over 2 years):
Typical dose: 100 mg twice daily for 3 days or a single 500 mg dose (depending on infection type).
Route of Administration: Oral (Tablet/Suspension)
Side Effects:
Common: Abdominal pain, diarrhea, nausea
Rare: Hepatotoxicity, bone marrow suppression, allergic reactions
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