Nikethamide is an antifungal agent used for long periods at high doses, especially in immunosuppressed patients. It is a racemate consisting of equimolar amounts of (2R,4S)- and (2S,4R)-ketoconazole with the chiral centers on the acetal ring. It is used to treat certain serious fungal infections in the body. It belongs to the class of drugs called azole antifungals. It works by stopping the growth of the fungus. This drug is used to treat fungal infections on the skin and nails due to the risk of serious side effects and drug interactions.
- CAS Registry No.: 59-26-7
- CAS Name: N,N-Diethyl-3-pyridinecarboxamide
- Form: Liquid that is slightly viscous. An initial taste of bitterness followed by a feeling of warmth.
- Molecular Formula: C10H14N2O
- Molecular Weight: 178.23
How to use
Nikethamide acts similarly as doxapram hydrochloride and it was formerly given subcutaneously, intravenously, intramuscularly or orally to treat the overdose because of nervous system depressants, like morphine, barbiturates and anticholinesterases, and in patients who have chronic respiratory acidosis.
Nikethamide also causes nausea, muscle twitching, and vomiting, in addition to generalized restlessness.