Norethisterone Acetate

About Norethisterone Acetate

We are offering high quality of Norethisterone Acetate. We are known for manufacturing,exporting, distributing, trading and supplying Norethisterone Acetate in Gujarat, India. Further, this is safely packaged by our professionals in diverse packaging options that maintain its purity and effectiveness.

Shreeji Pharma International is leading Manufacturer, Exporter, Distributor, and Supplier of Norethisterone Acetate in Gujarat. India. Shreeji Pharma International manufacturing & supplying all products under GMP site with all types of regulatory supports.

Shreeji Pharma International is the largest manufacturer, Exporter and supplier of Norethisterone Acetate Nowadays Shreeji Pharma International is one of the leading manufacturer and exporter, who is manufacturing Norethisterone Acetate as well as Intermediates of Norethisterone Acetate.

Shreeji Pharma International is exporter, supplier, distributor and manufacturers of the Active Pharmaceuticals Ingredients in many countries for many years.

Shreeji Pharma International currently export Norethisterone Acetate to countries like Gulf Countries, South East Asia countries, African Countries, CIS Countries, LATAMcountries, Central American Countries and in European countries

• Chemical Name:17-Acetoxy-19-nor-17-pregn-4-en-20-yn-3-one
• Common Names:Norethisterone Acetate
• Norethindrone Acetate (U.S. adopted name)
• NET Acetate
• CAS Number: 51-98-9
• Molecular Formula: C22H28O3
• Molecular Weight: 340.46 g/mol
• Appearance: White to off-white crystalline powder
• Odor: Odorless
• Solubility:Practically insoluble in water
• Soluble in ethanol, acetone, chloroform, and other organic solvents
• Melting Point: 160164C
• Storage Conditions:Store in a tightly sealed container at controlled room temperature (2025C), protected from light and moisture.
• Pharmacological Classification:
• Class: Synthetic progestin (progestogen)
• Therapeutic Category: Hormonal drug, contraceptive, gynecological hormone
• Mechanism of Action:Norethisterone acetate is a prodrug of norethisterone. After administration, it is hydrolyzed to its active form. It:
• Binds to intracellular progesterone receptors
• Inhibits ovulation by suppressing gonadotropin release
• Alters cervical mucus and endometrial lining to prevent fertilization and implantation

Applications:

• Used as an Active Pharmaceutical Ingredient (API) in:
• Oral contraceptives (either progestin-only or combined with estrogen)
• Hormone Replacement Therapy (HRT) for menopausal symptoms
• Gynecological conditions such as:Endometriosis
• Dysfunctional uterine bleeding
• Amenorrhea
• Premenstrual syndrome (PMS)
• Available in tablet formulations (typically 5 mg, 10 mg)

Key Properties:

• High oral bioavailability
• Longer half-life compared to norethisterone
• Stronger progestational activity due to acetate group
• Stable and effective in small doses

• Common:Nausea, headache, dizziness,Breast tenderness,Irregular uterine bleeding
• Mood changes,Less common:,Weight gain, bloating,Acne, oily skin (due to mild androgenic activity)
• Libido changes

Rare but serious:Thromboembolic events,Liver dysfunction,Allergic skin reactions

Precautions & Warnings:

• Contraindications:Known or suspected pregnancy,History of thromboembolic disorders,Severe liver disease or hepatic tumors,Estrogen- or progesterone-sensitive cancers,Undiagnosed vaginal bleeding
• Use with caution in: Smokers (especially over age 35),Diabetics
• Patients with cardiovascular, renal, or psychiatric conditions
• Long-term use should be supervised by a healthcare provider