Norethisterone Chemical

About Norethisterone Chemical

We are offering high quality of Norethisterone. We are known for manufacturing,exporting, distributing, trading and supplying Norethisterone in Gujarat, India. Further, this is safely packaged by our professionals in diverse packaging options that maintain its purity and effectiveness.

Shreeji Pharma International is leading Manufacturer, Exporter, Distributor, and Supplier of Norethisterone in Gujarat. India. Shreeji Pharma International manufacturing & supplying all products under GMP site with all types of regulatory supports.

Shreeji Pharma International is the largest manufacturer, Exporter and supplier of Norethisterone Nowadays Shreeji Pharma International is one of the leading manufacturer and exporter, who is manufacturing Norethisterone as well as Intermediates of Norethisterone.

Shreeji Pharma International is exporter, supplier, distributor and manufacturers of the Active Pharmaceuticals Ingredients in many countries for many years. Shreeji Pharma International currently export Norethisterone to countries like Gulf Countries, South East Asia countries, African Countries, CIS Countries, LATAMcountries, Central American Countries and in European countries

• Chemical Name: (17)-17-Hydroxy-19-nor-17-pregn-4-en-20-yn-3-one
• Common Names: Norethisterone Norethindrone (U.S. adopted name) 17-Ethynyl-19-nortestosterone 
• CAS Number: 68-22-4
• Molecular Formula: C20H26O2
• Molecular Weight: 298.42 g/mol
• Appearance: White to off-white crystalline powder
• Odor: Odorless
• Solubility: Insoluble in water; soluble in ethanol, methanol, chloroform, and acetone
• Melting Point: 205210C
• Storage Conditions: Store in a cool, dry place (controlled room temperature 2025C), in a tightly sealed container protected from light and moisture

Pharmacological Classification:

• Class: Synthetic progestogen (Progestin)
• Therapeutic Category: Hormonal contraceptive, gynecological hormone
• Mechanism of Action:Norethisterone mimics the effects of natural progesterone. It binds to progesterone receptors, resulting in:
• Suppression of ovulation
• Thickening of cervical mucus (preventing sperm penetration)
• Alteration of endometrial lining (preventing implantation)

Applications:

• Used as an Active Pharmaceutical Ingredient (API) in:
• Oral contraceptives (both progestin-only and combined estrogen-progestin pills)

Treatment of:

• Menstrual disorders (amenorrhea, menorrhagia, dysmenorrhea)
• Endometriosis
• Hormone replacement therapy (HRT)
• Premenstrual syndrome (PMS)
• Available in tablet and injectable formulations (often in combination with estrogens or other steroids)

Properties:

• High oral bioavailability
• Rapid absorption, hepatic metabolism
• Long half-life (612 hours) depending on dose and route
• Side Effects:Common: Nausea, headache, breast tenderness, weight changes
• Irregular menstrual bleeding or spotting
• Mood swings, acne, libido changes
• Rare: Thromboembolic disorders, liver enzyme changes
• Androgenic effects (mild): hirsutism, oily skin (especially at higher doses)

Precautions & Warnings:

Contraindicated in:

• Known or suspected pregnancy
• History of thromboembolic disease
• Severe liver dysfunction or tumors
• Undiagnosed vaginal bleeding
• Estrogen/progestin-sensitive cancers (breast, endometrium)

Caution in:

• Hypertension, diabetes, migraines, depression
• Smokers over 35 years (risk of thrombosis)
• Requires periodic monitoring in long-term