Promethazine Hydrochloride

Product Description

We are offering high quality of Promethazine Hcl. We are known for manufacturing, exporting, distributing, trading and supplying Promethazine Hcl  in Gujarat, India. Further, this is safely packaged by our professionals in diverse packaging options that maintain its purity and effectiveness.

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Promethazine Hydrochloride (Promethazine HCl) is a medication used to treat a variety of conditions, including allergic reactions, nausea, vomiting, motion sickness, and sleep disorders. It is classified as an antihistamine, but it also possesses sedative, antiemetic (anti-nausea), and anticholinergic properties. Below is a detailed description of Promethazine HCl:

Chemical Composition:

Name: Promethazine Hydrochloride

Chemical Formula: C17H20N2SHCl

Molecular Weight: 320.88 g/mol

IUPAC Name: 10-(3-dimethylaminopropyl) phenothiazine hydrochloride

Physical Properties:

Appearance: Promethazine HCl is typically a white to off-white crystalline powder.

Solubility: It is freely soluble in water and alcohol, but slightly soluble in chloroform and ether.

Melting Point: Approximately 180-183C (decomposes).

pH: When dissolved in water, the pH is usually between 4.5 and 5.5 for an injectable solution.

Uses:

Promethazine HCl is widely used for a variety of medical purposes, including:

Allergic Reactions: It can be used to treat symptoms of hay fever, rhinitis, and other allergic conditions by blocking the effects of histamine.

Motion Sickness: Promethazine is often prescribed for the prevention and treatment of nausea and vomiting associated with motion sickness.

Nausea and Vomiting: It is commonly used to prevent and treat nausea and vomiting caused by anesthesia, surgery, or chemotherapy.

Sedation: Due to its sedative effects, it can be used as a short-term sleep aid or for its calming effects.

Preoperative Sedation: In the medical setting, it is used as a sedative before and after surgery to reduce anxiety and prevent nausea.

Cough and Cold Relief: Sometimes, it is used in combination with other medications to treat symptoms of the common cold or flu.

Mechanism of Action:

Promethazine works by blocking the action of histamine at the H1 receptor site. Histamine is a chemical in the body that is responsible for allergic symptoms like itching, swelling, and runny nose. By blocking histamine, promethazine alleviates these symptoms. Additionally, its sedative properties are due to its ability to cross the blood-brain barrier and depress the central nervous system.

Promethazine also has anticholinergic effects, which means it blocks the action of acetylcholine, a neurotransmitter involved in various body functions, including muscle movement and secretions. This contributes to its antiemetic (anti-nausea) effects and can help reduce motion sickness symptoms.

Dosage and Administration:

Promethazine HCl is available in several forms, including oral tablets, syrup, and injectable forms.

Oral Tablets: Promethazine is typically prescribed in 12.5 mg, 25 mg, or 50 mg tablets. The usual dose depends on the condition being treated and the patient's response. For example, for allergies, doses may range from 25 mg to 50 mg daily.

Oral Syrup: The syrup form is often used for children and provides an easier way to adjust doses based on age or weight. The dosage for children will generally be lower and based on weight.

Injectable Form: For conditions requiring rapid treatment (e.g., severe nausea or allergic reactions), promethazine may be injected intramuscularly or intravenously. The injection is typically administered by a healthcare professional.

Dosage Considerations: The exact dosage will depend on the medical condition being treated, the patient's age, and overall health. Always follow the prescribed dosage and avoid exceeding recommended amounts.

Precautions:

Allergy to Promethazine: Individuals who have a known allergy to promethazine or other phenothiazines should not use this medication.

Sedation and Drowsiness: Promethazine can cause significant drowsiness and sedation, so it is important to avoid activities that require full alertness (e.g., driving) while on this medication.

Elderly Patients: Older adults may be more susceptible to side effects like sedation, confusion, and low blood pressure.