Pyrazinamide

About Pyrazinamide

We are offering high quality of Pyrazinamide Api Powder. We are known for manufacturing, exporting, distributing, trading and supplying Pyrazinamide Api Powder  in Gujarat, India. Further, this is safely packaged by our professionals in diverse packaging options that maintain its purity and effectiveness.

Shreeji Pharma International is leading Manufacturer, Exporter, Distributor, and Supplier Pyrazinamide Api Powder in Gujarat. India. Shreeji Pharma International manufacturing & gmp; supplying all products under GMP site with all types of regulatory supports.

Shreeji Pharma International is the largest manufacturer, Exporter and supplier of Pyrazinamide Api Powder. Nowadays Shreeji Pharma International is one of the leading manufacturer and exporter, who are manufacturing Pyrazinamide Api Powder as well as Intermediates of Pyrazinamide Api Powder.  

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Shreeji Pharma International currently exports Pyrazinamide Api Powder to countries like Gulf Countries, South East Asia countries, African Countries, CIS Countries, LATAM countries, Central American Countries and in European countries.

General Information:

Pyrazinamide is an essential first-line anti-tuberculosis (TB) medication used in combination with other drugs for the treatment of Mycobacterium tuberculosis infections. It is a prodrug that is converted into its active form, pyrazinoic acid, within the bacterial cell, disrupting bacterial growth.

Chemical Properties:

Chemical Name: Pyrazine-2-carboxamide

Molecular Formula: CHNO

Molecular Weight: 123.11 g/mol

CAS Number: 98-96-4

Appearance: White to pale yellow crystalline powder

Solubility: Soluble in water and ethanol, slightly soluble in ether

Melting Point: 189192C

Mechanism of Action:

Pyrazinamide is a prodrug that is activated by bacterial pyrazinamidase (PncA) to pyrazinoic acid (POA), which disrupts membrane potential and intracellular pH homeostasis in Mycobacterium tuberculosis, leading to bacterial cell death. It is most effective in acidic environments, making it especially useful against TB bacteria in macrophages and necrotic lung lesions.

Pharmacokinetics:

Absorption: Well absorbed orally

Metabolism: Primarily metabolized in the liver to pyrazinoic acid

Excretion: Eliminated through urine (mainly as metabolites)

Half-life: 910 hours (may be prolonged in renal impairment)

Therapeutic Uses & Indications:

Treatment of active tuberculosis (TB)

Always used in combination with other TB drugs (e.g., rifampicin, isoniazid, ethambutol) to prevent drug resistance

Works effectively against dormant TB bacteria within acidic lesions

Dosage & Administration:

Adults:

Standard dose: 1530 mg/kg per day (maximum 2 g/day)

Intermittent therapy (twice weekly): 5070 mg/kg

Pediatric dosage: 1530 mg/kg per day

Administration: Taken orally, usually once daily with food to reduce gastrointestinal side effects

Side Effects:

Hepatotoxicity (most serious risk) liver enzyme elevation, jaundice, hepatitis

Hyperuricemia (may cause gout attacks)

Gastrointestinal disturbances nausea, vomiting, loss of appetite

Arthralgia (joint pain)

Skin rash, photosensitivity

Precautions & Contraindications:

Contraindicated in:

Severe liver disease

Acute gout

Use with caution in:

Patients with kidney impairment

Pregnant or breastfeeding women (only if benefits outweigh risks)

Drug Interactions:

Rifampicin & Isoniazid: Increased risk of liver toxicity

Allopurinol & Probenecid: May affect uric acid levels

Alcohol: Increases liver toxicity risk

Storage & Stability:

Store at room temperature (1530C)

Keep in a tightly closed container, away from light and moisture