It is a sulfa derivative topical antibacterial used primarily on second- and third-degree burns. We have gained huge fame amongst our customers as a trustworthy organization engaged in offering Silver Sulfadiazine. This drug has broad antimicrobial activity. It is bactericidal for many gram- negative and gram-positive bacteria as well as being effective against yeast. It is not a carbonic anhydrase inhibitor and may be useful in situations where such agents are contraindicated. It acts only on the cell membrane and cell wall to produce its bactericidal effect.
Silver Sulfadiazine Properties:
- CAS Number: 13078-82-5
- Name: Benzeneethanamine,4-amino-, hydrochloride (1:2)
- Superlist Name: 2-(4-Aminophenyl)ethylamine dihydrochloride
- Formula: C10H9AgN4O2S
- Molecular Weight: 209.12
- Synonyms: p-amino-, dihydrochloride(7CI,8CI);4-(2-Aminoethyl)aniline dihydrochloride;Benzeneethanamine,4-amino-, dihydrochloride (9CI);4-Aminophenethylamine dihydrochloride;4-Aminobenzeneethanaminedihydrochloride;
How does it work
Patients with burn injuries are prescribed silver sulfadiazine together with other treatments to help prevent infection in their wound. An open wound can be infected with silver sulfadiazine since it prevents bacteria from growing. The bacteria are prevented from spreading throughout the skin or into the blood stream, causing a serious blood infection (sepsis). Silver sulfadiazine belongs to a class of drugs called sulfa antibiotics. Silver sulfadiazine should be avoided for premature babies and newborns between 2 months and one year of age due to the risk of serious side effects.
Applications Or where it is used
With second- and third-degree burns, silver sulfadiazine cream prevents and treats wound infections. In the event of severe burns or large areas of burns on the body, treatment in a hospital is required. Antibiotics such as silver sulfadiazine are used in treating bacterial infections. Bacteria are killed or prevented from growing by it
Silver sulfadiazine can be used in burn therapy if applied to the affected surface as a dispersion in a water-dispersible hydrophilic carrier.
An improved topical pharmaceutical composition for treating burns or microbial infections on humans or animals is provided. A pharmaceutical composition contains 0.1% - 1% w/w silver sulfadiazine as an antimicrobial drug and 0.2% w/w chlorhexidine gluconate as an antiseptic; silver sulfadiazine is nanonized.
How to use
Apply a thin layer of silver sulfadiazine (about 1/16 inch) to the affected areas. The medicine should always be applied to the affected areas. You must reapply this medicine if it has been washed off by moving around or by bathing, showering, or using a whirlpool bath.
Dosage of usage
Dosages of Silver Sulfadiazine:
Adult and Pediatric:
Burn wound infections (2nd degree/3rd degree)
1% cream: apply daily every 12 hours to burn
Infants under 2 months: contraindicated
Infants over 2 months (1% cream): Apply daily every 12 hours to burn
Common side effects include:
- Adverse nervous system effects
- Acute kidney failure
- Kidney swelling
- Burning sensation
- Cell death of the skin
- Localized eruption of the skin
- Transient skin discoloration
- Destruction of red blood cells (in patients with G6PD deficiency)
- Deficiency of granulocytes in the blood
- Discontinued production of blood cells
- Low blood platelet count
- Low white blood cell count
- Adverse gastrointestinal effects
- Liver inflammation
- Toxic injury to the liver
- Presence of harmful bacteria via infection of a wound (sepsis)
Warnings and precautions while using this product
A silver sulfadiazine component is present in this medicine. When you are allergic to silver sulfadiazine or any of the other ingredients in this drug, you should not use Silvadene, Thermazene, or SSD Cream.
Keep out of the reach of children. Obtain medical attention or contact the Poison Control Center immediately if you overdose.
- Sulfa allergy.
- G6PD deficiency.
- If you are pregnant or nursing near term, or the baby or infant is premature, or you are less than two months old, please avoid the use of suflanomides.