Erythromycin Stearate Powder

Product Description

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- Technical Specifications :

 Name:Erythromycin stearate

CAS No.:643-22-1

Formula:C₃₇H₆₇NO₁₃^.C₁₈H₃₆O₂

Molecular Weight:1018.40

Erythromycin Stearate is a macrolide antibiotic used for the treatment of various bacterial infections. It is the stearate ester form of erythromycin, which improves its stability and bioavailability compared to other forms of erythromycin, such as erythromycin base. It is often used as an oral formulation for treating respiratory tract infections, skin infections, and other conditions caused by susceptible organisms.

Heres a detailed description of Erythromycin Stearate Powder:

Chemical Name:

Erythromycin Stearate.

Molecular Formula:

C37H67NO13.

Chemical Structure:

Erythromycin stearate is a stearic acid ester of erythromycin, meaning the erythromycin molecule is bonded to a stearic acid group (a saturated fatty acid with 18 carbon atoms) through an ester linkage. This esterification enhances its properties for oral administration.

Appearance:

Erythromycin stearate typically appears as a white to off-white crystalline powder. It is generally available in tablet or powder form for reconstitution.

Dosage and Administration:

Erythromycin stearate is usually taken orally, and the dose may vary based on the severity of the infection and the patient's condition.

Typical Adult Dosage:

For respiratory infections, the typical dose might be 250 mg to 500 mg every 6 hours.

The duration of treatment typically ranges from 7 to 14 days, depending on the type of infection and response to treatment.

Pediatric Dosage:

The dosage is usually 10-20 mg/kg/day, divided into multiple doses.

Exact dosing should be determined by a healthcare provider based on weight and the infection being treated.

Side Effects:

Common side effects of erythromycin stearate include:

Gastrointestinal disturbances: Nausea, vomiting, diarrhea, and abdominal pain are common side effects.

Liver toxicity: Erythromycin can cause an elevation of liver enzymes, and in rare cases, it can lead to liver damage.

Allergic reactions: Rash, itching, and in some cases, severe reactions like anaphylaxis or angioedema (swelling of deeper layers of the skin).

Hearing loss: High doses of erythromycin can cause temporary or permanent hearing loss, particularly in patients with renal impairment.

QT prolongation: Erythromycin can prolong the QT interval in some patients, which can lead to arrhythmias (irregular heartbeats).

Precautions:

Liver disease: Caution should be taken in patients with liver problems, as erythromycin is metabolized by the liver. Liver function tests may be required before and during treatment.

Drug interactions: Erythromycin can interact with several drugs due to its inhibition of the CYP450 3A4 enzyme system. This can increase the plasma levels of drugs like warfarin, theophylline, benzodiazepines, and statins.

QT prolongation: Due to the potential for QT prolongation, erythromycin should be used with caution in patients with a history of heart disease, especially if they are also taking other drugs that prolong the QT interval.

Allergic reactions: If any signs of a severe allergic reaction (such as difficulty breathing, swelling, or hives) occur, discontinue use and seek medical attention immediately.

Storage:

Erythromycin stearate powder or tablets should be stored in a cool, dry place, typically at room temperature (20C to 25C or 68F to 77F).

It should be kept in airtight containers to protect it from moisture and degradation.