Rivaroxaban Chemical

Product Description

We are offering high quality of Rivaroxaban. We are known for manufacturing,exporting, distributing, trading and supplying Rivaroxaban in Gujarat, India. Further, this is safely packaged by our professionals in diverse packaging options that maintain its purity and effectiveness.

Shreeji Pharma International is leading Manufacturer, Exporter, Distributor, and Supplier of Rivaroxaban in Gujarat. India. Shreeji Pharma International manufacturing & supplying all products under GMP site with all types of regulatory supports.

Shreeji Pharma International is the largest manufacturer, Exporter and supplier of Rivaroxaban Nowadays Shreeji Pharma International is one of the leading manufacturer and exporter, who is manufacturing Rivaroxaban as well as Intermediates of Rivaroxaban.

Shreeji Pharma International is exporter, supplier, distributor and manufacturers of the Active Pharmaceuticals Ingredients in many countries for many years.

Shreeji Pharma International currently export Rivaroxaban to countries like Gulf Countries, South East Asia countries, African Countries, CIS Countries, LATAMcountries, Central American Countries and in European countries.

Rivaroxaban is a synthetic, orally active anticoagulant used in the prevention and treatment of thromboembolic disorders. It belongs to a class of drugs known as direct oral anticoagulants (DOACs) or non-vitamin K antagonist oral anticoagulants (NOACs) and functions by selectively inhibiting Factor Xa, a crucial enzyme in the blood coagulation cascade.

Rivaroxaban (CAS No. 366789-02-8) is a direct oral anticoagulant (DOAC) that acts as a selective inhibitor of Factor Xa, playing a crucial role in the prevention and treatment of thromboembolic disorders. Below is a detailed technical overview of Rivaroxaban powder, focusing on its chemical properties, specifications, and applications:

• Molecular Formula: CHClNOS
• Molecular Weight: 435.88 g/mol
• Appearance: White to light yellow crystalline powder
• Melting Point: 230234C
• Specific Rotation: -40.0 to -44.0 (C=1, DMSO)
• Solubility:Practically insoluble in water Soluble in dimethylformamide (DMF)
• Slightly soluble in organic solvents like acetone and polyethylene glycol 400
• Optical Activity: []D -34 to -44 (c = 0.3 in DMSO)
• Purity (HPLC): 98.0%
• Assay: 98.0% 102.0% (anhydrous substance)
• Total Impurities: 0.3%
• Single Impurity: 0.1%
• Loss on Drying: 0.5%
• Residue on Ignition: 0.1%
• Heavy Metals: 20 ppm
• Specific Optical Rotation: 39 to -42
• Structural & Functional Insights
• Enantiomer: Pure (S)-enantiomer
• Polymorphism: Crystallizes in three polymorphs; Polymorph I is the thermodynamically stable form used in tablet formulations
• Stability: Air and heat-sensitive; store under inert gas and refrigerated (010C)
• Storage Conditions: Refrigerated (28C); store in tightly sealed containers away from light and moisture

Mechanism of Action : Rivaroxaban inhibits Factor Xa, a key enzyme in the coagulation cascade, thereby reducing thrombin generation and preventing clot formation. It is highly selective for Factor Xa, with an IC of 0.7 nM, and shows no activity against thrombin, trypsin, plasmin, or other coagulation factors up to 20 M .

Applications in Medicine : Rivaroxaban is utilized in various clinical scenarios, including:Prevention and treatment of deep vein thrombosis (DVT) and pulmonary embolism (PE),Stroke prevention in patients with nonvalvular atrial fibrillation (NVAF),Prevention of venous thromboembolism in patients undergoing hip or knee replacement surgery