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Cellulose Acetate Phthalate Properties:
- Synonyms: Aquateric
- CAS NO.: 9004-38-0
- EINECS: 618-382-8
- Molecular Weight: 678.58992
- Molecular Formula: C28H38O19
- Appearance: White or off-white powder
Introduction of product:
Also known as known as cellacefate (INN) and cellulosi acetas phthalas, cellulose acetate phthalate (CAP), is a polymer phthalate commonly used in pharmaceutical formulations, such as enteric coating for tablets and capsules and in controlled release formulations. It can be dissolved in buffer solutions with pH values as low as 6. Consequently, it has found use in enteric coatings. Adding plasticizers makes the ester more water-resistant.
How does it work:
Cellulose acetate phthalate can be used in many ways, for instance as a microencapsulation agent, as an enteric film-coating material, or as a matrix binder for tablets and capsules. They won't dissolve under mildly acidic conditions in the intestine, but will dissolve in strongly acidic gastric fluid. Acetic acid, acetone, and pyridine are some of the organic solvents commonly used in the phthaloylation of cellulose acetate. Anhydrous sodium acetate is one of the basic catalysts used when using acetic acid, amines is another when using acetone, and the organic solvent as well when using pyridine as reaction medium.
Applications Or where it is used:
The cellulose acetate phthalate (CAP) material is used for enteric coatings or as a matrix binder for tablets and capsules. Surface coatings such as these resist contact with highly acidic gastric fluids, but dissolve in mildly acidic or neutral intestinal environments.
Cellulose acetate phthalate is applied to solid-dosage forms by two, one by by coating from organic or aqueous solvent systems, and other by direct compression. Concentrations generally range from 0.5 to 9.0% of the core weight. Plasticizers improve the water resistance of this coating material. Formulations using plasticizers outperform its formulations alone.
It is compatible with many plasticizers, such as:
- Acetylated monoglyceride
- Butyl phthalybutyl glycolate
- Dibutyl tartrate
- Diethyl phthalate
- Dimethyl phthalate
- Ethyl phthalylethyl glycolate
- Glycerin; propylene glycol
- Triacetin citrate
The compound can also be used as part of another coating agent, such as cellulose, in preparations for controlled-release drugs.
In terms of therapeutic application, cellulose acetate phthalate recently demonstrated experimental microbicidal activity against sexually transmitted disease pathogens, such as the HIV-1 retrovirus.
Wood pulp is converted into cellulose acetate by reaction with acetic acid and acetic anhydride in the presence of sulfuric acid. Hydrolysis of the triacetate is then carried out to achieve the desired substitution level.